WS 17 bio

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University of Utah *

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1610

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Biology

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Dec 6, 2023

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docx

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Name uNID Worksheet 17 Meiosis and Mendel Work together but each student must complete and turn in their own worksheet. 1. Start with a diploid “parent” cell that has two chromosomes as pictured below. 2n=2 means that this diploid cell has two same-sized, homologous chromosomes. Fill in the circles below. Just draw chromosomes, no spindles or nuclear envelope. Label “A” and “a” representing alternate alleles of same gene on homologs in each cell. Use a vertical metaphase plate. Label each cell type as haploid (1n) or diploid (2n)= number of chromosomes, and amount of DNA (__ x) compared to a 1x gamete U1453615 Coleman Stettler
2. There are two pairs of chromosomes in this diploid cell (2n=4). Label the genes and alleles on homologs and sister chromatids. A is on the big chromosome and B is on the smaller chromosome. The genotype is AaBb. Using a vertical metaphase plate, draw the two independent orientations of this AaBb cell in Metaphase I of MEIOSIS. OR GAMETES: ________ ________ ________ ________ On the lines above, indicate the genes/alleles in the gametes (after cytokinesis II) that would results from that alignment in the circles above (no crossover has occurred). 3. Draw replicated chromosomes in a cell that is 2n=6 versus one that is 3n=6. (hint: first solve for 1n=_____ and draw the chromosomes in the appropriate haploid cells. Make non-homologs different sizes) GENETICS SENARIO: (this is long. If you run out of time in discussion please on your own or with help in study hall. This will be easier after class 19) The gene involved in the disease Sickle Cell Anemia (SCA) is on human chromosome 11. Allele “ A ” is the normal form of the gene and codes for a part of the protein complex called hemoglobin. Hemoglobin is required for your blood cells to carry oxygen. Allele “a” is an abnormal form of the gene. The hemoglobin protein made from the “ a ” allele is defective. Red blood cells containing the defective protein are very fragile. This disease is recessive–meaning that you have to inherit two copies of the recessive allele in order to be affected with the disease SCA. The gene involved in the disease Cystic Fibrosis (CF) is on human chromosome 7. Allele “ B ” is the normal form of the gene and codes for a channel protein that allows chloride to pass through a cell. Allele “ b ” is the abnormal form of the gene. The channel protein made from the “b” allele is defective and doesn’t insert into the cell’s plasma membrane, resulting in an inability of chloride to cross the membrane. CF is also recessive therefore only people with two defective copies of the gene (“bb”) are affected with the disease.
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