preview

Argument Against Viruses

Decent Essays

The antagonist of this story is unlike the villains we know. In fact, they can’t even be seen with the naked eye. They are viruses. Viruses are non-cellular genetic elements that hijack a host cell in order to use their molecular machinery to reproduce and cause infection. Therefore, by definition, viruses cause a reduction in the fitness of their host. Because viruses harm their host, natural selection favors host genes that make them resistant to viruses. Consequently, this places a selection pressure on the virus to overcome the hosts’ resistance. Simultaneous mutations between the two species enters them into an evolutionary arms race, with the host developing resistance in order to overcome the virus and the virus developing new ways to overcome this resistance – typically though mutation – in order to persist and reproduce. This cycle is known as antagonistic coevolution.
In …show more content…

Using serial passage, the FV complex had the opportunity to adapt to their hosts’ MHC genotype and with this opportunity the virus developed significantly higher fitness, in addition to having increased virulence. The same viral strain subsequently showed decreased fitness and a reduction in the amount of new viral particles they were able to reproduce, when they were exposed to an unfamiliar MHC host genotype. These results correspond to the two assumptions – a trade-off and increased virulence – made under the antagonistic coevolution model and show that there is a selective advantage to a host which is carrying an unfamiliar MHC genotype. Their research demonstrated that increasing the genetic variation in host MHC genotypes can provide a significant obstacle to rapid evolving viral populations. If there is a reduction in host MHC-genotype diversity it can facilitate the evolution of more virulent

Get Access