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Brain Ischemia Essay

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The blood-brain barrier (BBB) is a metabolic and physical barrier between the central nervous system and the brain blood flow (1). The correct functioning of the BBB is crucial for keeping brain homeostasis and avoiding many poisons and pathogens (2). During cerebral ischemia, BBB disruption is a crucial event that induces an influx of water, resulting in vasogenic edema (3), and causes supplementary brain harm such as dementia through accumulation of beta-amyloid peptide (4). Brain edema aggravates the development of infarct development and causes herniation and loss of life (5). It's been reported that reactive oxygen species (ROS) exert deleterious activities, such as BBB disruption and BBB hyperpermeability, during vasogenic edema (6). …show more content…

Furthermore, inhibition of ROS protects TJs against disruption during brain damage (8). Furthermore, amelioration of ischemia-induced BBB disruption and brain edema in addition has been shown by using diet antioxidants such as olive leaf extract and ginkgo biloba extract (9, 10). Matricaria chamomilla can be an aroma herb with anticancer, antioxidant, and anti inflammatory properties (11), is an important source of dietary antioxidants (12). Various studies show that matricaria chamomilla is associated with several health advantages such as antioxidants (13), and cancer (14). However, to the best of our knowledge, little is well known about the result of matricaria chamomilla extract on BBB dysfunction during brain ischemia. In the present study, we looked into whether matricaria chamomilla extract has beneficial results on brain ischemia-induced edema and BBB dysfunction in mice. The possible root systems are also looked into, especially those from the antioxidant ramifications of the matricaria chamomilla

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