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Cognitive Impairmentia

Decent Essays

The study I chose as a topic to discuss is the study of cross-validation of biomarkers for the early differential diagnosis and prognosis of dementia in a clinical setting, which was conducted by Daniela Perani, Chiara Cerami, Silvia Paola Caminiti, Roberto Santangelo, Elisabetta Coppi, Laura Ferrari, Patrizia Pinto, Gabriella Passerine, Andrea Falini, Sandro Iannaccone, Stefano Francesco Cappa, Giancarlo Comi, Luigi Gianolli, and Giuseppe Magnani. The study was designed to evaluate the role of support that molecular and structural biomarkers which is CSF protein levels, FDG, PET, and MRI, during the beginning differential diagnosis of dementia. A large number of patient were tested, who all had neurodegenerative dementia. Determining the risk of the disease progressing also was tested in subjects with mild cognitive impairment (MCI). …show more content…

The MCI progression was also evaluated. The results were somewhat on the positive side. A diagnosis that was based on molecular biomarkers showed the best fit with the end diagnosis at a long follow up. The t-maps had the best and highest diagnostic accuracy in Alzheimer’s disease, and different non-alzheimer dementias. A significant classification rate was provided for alzheimer’s disease, and it was provided by the p-tau/A[beta.sub.42 ratio. The best predictor of conversation to Alzheimer’s disease includes the Alzheimer’s disease positive metabolic pattern, which was portrayed by FDG PET SPM, and MCI. Since this study was taken place in a clinical setting, some of the clinical diagnostic accuracy improved by the FDG PET SPM t-maps, and the p-tau,A[beta].sub.42 ratio. Alzheimer’s disease had emerging diagnostic criteria, including the biomarkers which were just named and they hold a significant

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