Review of Research Paper on Metastasis of Cancerous Tumors

(p133-134, text). * Define metastasis. * Development of a secondary tumor in a location distant from the primary tumor. * Accomplished via lymphatic channels and circulation. * Trace the pathways for the hematologic and lymphatic spread of metastatic cancer cells. Evidence of disseminate disease presence in lymph that drain the tumor area, tumor cells lodge first in the initial lymph node that receives drainage from the tumor site, once in this lymph node cells may die b/c of the lack of a proper environment, remain dormant for unknown reasons, or grow in a discernible mass, If they survive and grow cancer cells, may spread from more distant lymph nodes to the thoracic duct, and the gain access to the blood vasculature, cancer cells may gain access to the blood vasculature from the initial node and more distant lymph nodes by way of tumor-associated blood vessels that may infiltrate the tumor mass. Sentinel

The phase of cancer at the point of diagnosis varies for different cancers. Therefore, staging is performed by means of various methods such as MRI (Magnetic resonance imaging), CT (Computed tomography), X-rays, blood tests and special surgery. The three main reasons why staging of cancer is performed are: it determines the depth of the disease, helps determine the treatment by the phase of the cancer and helps determine the patient's projection of treatment and survival.

Tis means that the cancer cells are only growing in the most superficial layer of tissue, without growing into deeper tissues. This is also known as in situ cancer or pre-cancer.

Some have argued that important information related to the way in which, and the rapidity in which, cancer cells metastases has been obtained by this study. But this has been highly debated (Standler, 1997).

The importance?s of staging cancer is to assist the doctor with planning appropriate treatments to fight the cancer and also helps determine is treatment is a necessary option for patients. ?Unfortunately cancer is an assembly of illnesses that can result in virtually any sign or symptom. However the signs and symptoms associated with cancer are dependent upon where the cancer is located, how big the cancer is, and how much of the cancer affects the organs and tissues that the cancer is found in. If a cancer has metastasized (spread) to other regions of the body the signs or symptoms will possibly appear their as well? (cancer.org).

Harmful tumors require quick regulation and treatment, as threatening developments may grow quickly and metastasize (spread all through the body) at a disturbing rate. Metastases are auxiliary tumors which can show up at any area all through the body, which is an immediate impact of disease spreading by means of blood and lymph hubs.

Name the cell-types that define carcinomas, sarcomas, lymphomas, and leukemia’s. Which type is most common?

Cancer is defined by the National Cancer Institute as the title given to a group of related diseases. All types of cancer are categorized by uncontrollable growth of cells that metastasize to surrounding tissues. Cancer can develop at almost any part of the human body and anyone can develop cancer, although risk typically increases with age because most cancers tend to require many years to develop. ?Typically, human cells tend to grow and divide and ultimately form new cells as the body needs them. When an organisms cells grow old or get damaged, the cells die, and new ones replace them. However when cancer develops, this orderly process gets reformatted. As cells increasingly get more irregular, old or damaged cells begin to survive when they should die, and new cells develop in the body when there is no need for them. These abnormal cells have the ability to divide without stopping and tend to result in growths called tumors?(cancer.gov). Cancerous tumors are defined as malignant meaning that they can spread to nearby tissues or metastasize to distant places in places within the body and form new cancerous tumors. There are over 100 forms of cancer and they are usually named after the organs or tissues where the cancers originate. Staging of cancer is used when describing the severity of a person?s cancer and is based upon the following

KNN method is used here for calculating the occurrence percentage of cancer by uploading the input in excel format. The input data has minimum and maximum ranges of tested values such as WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, RDWSD, DW, MPV, PLCR, PCT, NRBC, NEUT, LYMPH, MONO, EO, BASO, and IG. These values are compared with our dataset containing various ranges and the occurrence percentage is calculated. Let us consider the uploading file name as range.xls. For uploading the following steps to be performed,

Cancer is listed as the second most common cause of death in western countries; particularly, in adults. Though it has a long antiquity, its prevalence and incidence today is pervasive and the war on cancer has not been promising. Malignant neoplasia is characterized by uncontrolled growth and the ability to metastasize or spread from the original site. Cancer results from mutations that promote cell proliferation and inhibit cell adhesion (metastasis). According to the National Cancer Institute (2016), “Cancer can also spread regionally,

Since tumor instability is not only seen between the primary and relapse setting but also throughout tumor progression, this makes clinical decisions more difficult and makes taking biopsies in a consecutive manner in the advanced setting a very important step to optimize treatment decision making for patients (Lindstrom et al,

Malignant tumors are harmful to the body and need immediate action. They have an absence of a border and metastasize by growing in different parts of the body once they have traveled throughout the vascular system.

There are a wide variety of cancer types. They all have several things in common, however. Each cancer starts with cells that become abnormal or cancerous. These cells reproduce and form a mass of cancerous cells. This mass is called a tumor. When the cancerous cells spread, or metastasize, they can impact other tissues, organs, and systems of the body. A second commonality among cancers is that when they are detected early, they are easier to treat and the treatments are more likely to work. In many cases, a cancer that is caught early can be completely destroyed.

Various investigators have found cellular pleomorphic, stromal elements or the combination of histologous stromal elements or the combination of histological features to be prognostically useful [1,8,10,11]. According to Hawkins et al. Four features-high mitotic count, stromal overgrowth, severe nuclear pleomorphism and infiltrating margins were useful predictors for the development of metastases [8]. They also showed that the most reliable predictor for metastasis was the presence of stromal overgrowth, and a primary tumor with stromal overgrowth had a 72% risk of metastatic spread [8]. Here patients need a close follow up with a CT scan of the bones and lungs.

This ability of malign cancer to make their way across basement membrane and into blood vessels is what makes cancer so fatal and impossible to be cure by surgery alone. The result of metastasis and invasion in normal tissue by cancer cells are often seen as one of the distinctive features of malignancy (Ruoslahti 1996). Even though the ability of invasion and metastasis are one of the hallmarks for cancer, these abilities are not unique to cancer cells as it can also occur during the early development stage of the embryo, in healthy organisms and in many noncancerous diseases (Mareel & Leroy 2003). It does not matter whenever the organism has developed benign or malign cancer, all cancer cells have the ability to disturb the normal cell cycle and threaten the survival of the organism.