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3. Explain how angiotensin-converting enzyme (ACE) inhibitors work to control hypertension.
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- 4. The heart, kidney, brain, retina and arterial blood vessels are prime targets of hypertensive damage. Uncontrolled and untreated AH accelerates the damage to these organs and could cause their failure.5. Medicines used to treat high blood pressure include: Water pills (diuretics), Angiotensin-converting enzyme (ACE) inhibitors, Angiotensin II receptor blockers (ARBs), Calcium channel blockers, Alpha-beta blockers,and etc6. Aldosterone (ALD) is a hormone your adrenal glands release that helps regulate blood pressure by managing the levels of sodium and potassium in your blood.1. Describe hypertension?8. Explain four (4) Types of Angina ? With explanation
- 7. What physiological effect do drugs that inhibit ACE have? A. They stimulate formation of angiotensin II leading to release of ADH and aldosterone and widespread vasoconstriction B. They decrease blood pressure by inhibiting formation of angiotensin II C. They increase blood pressure by stimulating formation of angiotensin II D. They cause release of aldosterone E. They stimulate the release of ADH F. They cause widespread vasoconstriction This is not and will not be graded5. Some patients with hypertension are kept on a low-salt (low-sodium) diet. Propose an explanation for this therapy. Include the references in apa 7th style5. A patient you are monitoring has been on Telmisartan (Cozaar), an angiotensin receptor blocker for the man- agement of their hypertension. The drug must be metabolized by CYP2C9 or CYP3A4 from a 5-methanol to a 5-carboxylic acid to exhibit its effects. After 2 years of successful therapy, their blood pressure suddenly in- creases. Why might this occur and what would you sug- gest as a substitute?
- 7. Explain where erythropoietin is secreted, its function, and explanation of its mechanism and target organ.4. Hypertension: The pathogenesis of essential hypertension is multifactorial and highly complex. Factors that play an important role in the pathogenesis of hypertension include genetics, activation of neurohormonal systems such as the sympathetic nervous system and renin-angiotensin-aldosterone system, abnormalities of resistance vessels, obesity, and increased dietary salt intake. Drugs used to treat hypertension target pathways and receptors linked to many of these pathogenic factors. Four classes of antihypertensive drugs were discussed in lecture. (1) Name these four classes. (2) name a drug in each class (3) describe that drug’s mechanism of action. (answer in details and citation)2. Describe the mechanisms of blood pressure regulation in our body.
