Give Detailed Solution Explanation needed (don't give Handwritten answer) 1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the firststep of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary?b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true?ROH+ NaHRONa+ + H₂c) Why is NaH rather than NaOH used in this reaction?Fill in the missing parts of the Williamson reaction shown below.OH+ 2NaBr-+ H₂CH3

Solution - a) Alcohol is first converted into alkoxide because it is more basic than neutral alcohol…

1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the first step of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary? ROH+ NaHRONa+ + H₂ b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true? c) Why is NaH rather than NaOH used in this reaction?

1. a) The Williamson synthesis is a very important method to prepare asymmetric ethers. In the first step of this reaction the alcohol is converted to an alkoxide as shown. Why is this necessary? ROH+ NaHRONa+ + H₂ b) The Williamson synthesis works best if the alkyl halide is primary. Why is this true? c) Why is NaH rather than NaOH used in this reaction?

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 13E

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