1. In making genetic crosses, why is it important to identify the gametes that each individual can contribute? 2. Explain why you cannot always apply this statement in genetics: “What you see is what you get.”
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- 4. The flowers of 4 o'clock plants may be red, pink or white. Reds crossed to whites only produced pink offspring. When pink flowered plants were crossed with each other, they produced 113 red, 129 white, and 242 pink. It is hypothesized that these colors are controlled by a single gene pair of incompletely dominant alleles. Is this hypothesis acceptable on the basis of a Chi-square test? Show your solutions below. Chi computed value: Degree of freedom: (at a = 0.05) Chi tabulated value:4. You have two probes that detect RFLPS that are closely linked (that is, RFLP 1 and 2 tend to be passed on together). You have been asked to help settle a paternity case. The two possible fathers have the following RFLP pedigree. The child and mother are also probed with these two RFLP probes. Is one male more likely to be the father? If so, which one? Explain your reasoning. (The data below the pedigree are two Southern blots.) grandparents grandparents dad #1 dad #2 child mother Probe #1 Probe #2 ||4. The flowers of 4 o’clock plants may be red, pink or white. Reds crossed to whites only produced pink offspring. When pink flowered plants were crossed with each other, they produced 113 red, 129 white, and 242 pink. It is hypothesized that these colors are controlled by a single gene pair of incompletely dominant alleles. Is this hypothesis acceptable on the basis of a Chi-square test? Show your solutions below. Chi computed value: ________ Degree of freedom: _________ (at α = 0.05) Chi tabulated value: ________
- 5. A cross between two wild-type flies gave progeny all of which were wild type. When vg e they were test crossed to flies the following results were obtained: vg e (a) 4 of the test crosses gave wild type, vestigal ebony, vestigal and ebony in a 1:1:1:1 ratio. (b) 4 of the test crosses gave all wild type. (c) 4 of the test crosses gave vestigal and wild type in a 1:1 ratio. (d) 4 of the test crosses gave ebony and wild type in a 1:1 ratio. What are the genotypes of the original pair of wild-type flies?2. Be able to compare and contrast (discuss similarities and differences in) in your own words the terms genotype and phenotype, wild-type and mutant phenotypes. Step by step.2. How many genetically different kinds of gametes can an individual with each of the following genotypes produce? Assume each gene is on a separate pair of chromosomes. a. Genotype AA aa Aa AaBB Number of genetically different gametes Genotype Aa Bb AaBbCC Aa Bb Cc AaBb CcDdEeFf Number of genetically different gametes Given the information in the table above, what general rule exists for determining the number of different gametes an organism of a given genotype can produce? Explain.
- 4. In guinea pigs, the genes for coat texture and coat colour are found on separate chromosomes. The allele for rough coat is dominant to the allele for smooth coat. The allele for black coat is dominant to the allele for white coat. A black guinea pig with a rough coat was crossed with a white guinea pig with a rough coat. The cross was repeated on a number of occasions and the phenotypes of the offspring were as follows: 28 rough and black coats 31 rough and white coats 11 smooth and black coats 10 smooth and white coats Complete the genetic diagram to explain this cross. Use the following symbols to represent the alleles: R = rough B = black Parental phenotypes: rough and black coat Parental genotypes: Gametes: Offspring genotypes: . Offspring phenotypes: . Expected phenotypic ratio: r = smooth b = white X rough and white coat4. You have determined that the gene order for three linked genes being studied is A B C. The number of recombinants resulting from crossover between genes A and BC are 44 and 48, respectively, while the double-crossover progeny total 4 and 6. What is the recombination frequency between genes A and B if the total progeny from the cross is 1000? Show all of your work.1. It's a very well known fact that most dragons do not breathe fire, and it's also well known that alleles that enable fire breathing are recessive to the wild-type Sweet Breath phenotype. However, it's unclear how many different genes when mutated cause the fire breathing phenotype. To answer this question you use four different strains of dragon and perform a series of crosses. Your strains are the Hungarian Horntail (Strain A), the Norwegian Ridgeback (Strain B), the Romanian Longhorn (Strain C), and the Swedish Shortsnout (Strain D). All strains are true breeding for a single homozygous recessive mutation that allows them to breathe fire. Cross #1 Hungarian Horntail (A) X Norwegian Ridgeback (B) = F1: All Sweet Breath Cross #2 Romanian Longhorn (C) X Swedish Shortsnout (D) = F1: All Sweet Breath Cross #3 Swedish Shortsnout (D) X Norwegian Ridgeback (B) = F1: All Firebreathing Cross #4 Romanian Longhorn (C) X Hungarian Horntail (A) = F1: All Firebreathing How many genes are…
- 1. The first genetic test used a short DNA sequence that was closely linked to the Huntington’s locus. The linkage distance between the DNA sequence used in the test and the actual Huntington’ disease locus was 5%. a. In a large sample of the Venezuelan family (over 2,000 individuals), what percentage of people would inherit the DNA sequence but not the Huntington’s allele (i.e. be a false positive test for Huntington’s)? b. What percentage of that large Venezuelan family would not inherit the DNA sequence but would inherit the Huntington’s allele (i.e., be a false negative test for Huntington’s)?1. What is the difference between genotype and phenotype? 2. A black guinea pig is mated to a white guinea pig, and they produce 12 black offspring. Then, the same white guinea pig is mated to a different black guinea pig, and they produce 7 black and 5 white offspring. What is the best explanation for the difference between these two matings? In your answer, you must include the genotypes for the parents and offspring of each cross. 3. In 1981, a stray black cat with unusual curled-back ears was adopted by a family in California. Suppose you were the person who owned the first “curl” cat, and wanted to develop it into its own breed. How would you determine whether the allele for curled ears is dominant or recessive? Why does it make a difference for breeders whether an allele for a trait is dominant or recessive?6. There are two enzymes LDH1 and LDH2. The gene that encodes this enzyme is X-linked. You extract the enzyme from different cells in several people and carry out electrophoresis. Give the genotypes for each person Draw the banding pattern that you would expect in the gel. Male with Male with Female Female Heterozygous LDH1 gene homozygous female LDH2 homozygous for LDH2 for LDH1