1. LDA, -78 °C 2. PhCH₂Br (1 equiv) ☑ ☑ OH Select to Draw Please select a drawing or reagent from the question area Incorrect, 3 attempts remaining Under basic conditions, the proton alpha to a carbonyl is acidic. The conjugate base formed from this acid-base reaction is often used as a nucleophile in a subsequent substitution reaction. Review the reaction conditions and substrates keeping in mind any relevant stereochemistry or regiochemistry associated with this reaction. Consider counting carbons. Retry
1. LDA, -78 °C 2. PhCH₂Br (1 equiv) ☑ ☑ OH Select to Draw Please select a drawing or reagent from the question area Incorrect, 3 attempts remaining Under basic conditions, the proton alpha to a carbonyl is acidic. The conjugate base formed from this acid-base reaction is often used as a nucleophile in a subsequent substitution reaction. Review the reaction conditions and substrates keeping in mind any relevant stereochemistry or regiochemistry associated with this reaction. Consider counting carbons. Retry
Chapter22: Carbonyl Alpha-substitution Reactions
Section22.SE: Something Extra
Problem 64AP: The key step in a reported laboratory synthesis of sativene, a hydrocarbon isolated from the mold...
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