1. Make a Lineweaver-Burk plot and use the plot to complete the information in the table and the following questions.  a. Is it possible for the enzyme to overcome the effect of the inhibitor in question from the chart. Explain.  b. What prevents this enzyme from being an even more catalytically efficient enzyme? c. What do single molecule data indicate about the validity of ensemble data? d. What is the reason that humans are insensitive to sulfa drugs?

Nutrition Now
8th Edition
ISBN:9781337415408
Author:Brown
Publisher:Brown
Chapter21: Phytochemicals
Section: Chapter Questions
Problem 8RQ
icon
Related questions
Question

1. Make a Lineweaver-Burk plot and use the plot to complete the information in the table and the following questions. 

a. Is it possible for the enzyme to overcome the effect of the inhibitor in question from the chart. Explain. 

b. What prevents this enzyme from being an even more catalytically efficient enzyme?

c. What do single molecule data indicate about the validity of ensemble data?
d. What is the reason that humans are insensitive to sulfa drugs?

[S],
V, mm/sec
(no inhibitor)
mM
.5
12
2.0
20
5.0
29
13.5 35
45.0
40
V, mm/sec
(+inhibitor)
5.5
9
13
16
18
Reaction
No inhibitor
+ inhibitor
Type of
inhibition
Best fit line
equation
Km or
Km (app)
Vmax or
Vmax (app)
Transcribed Image Text:[S], V, mm/sec (no inhibitor) mM .5 12 2.0 20 5.0 29 13.5 35 45.0 40 V, mm/sec (+inhibitor) 5.5 9 13 16 18 Reaction No inhibitor + inhibitor Type of inhibition Best fit line equation Km or Km (app) Vmax or Vmax (app)
Expert Solution
steps

Step by step

Solved in 3 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Nutrition Now
Nutrition Now
Health & Nutrition
ISBN:
9781337415408
Author:
Brown
Publisher:
Cengage
Curren'S Math For Meds: Dosages & Sol
Curren'S Math For Meds: Dosages & Sol
Nursing
ISBN:
9781305143531
Author:
CURREN
Publisher:
Cengage
Essentials of Pharmacology for Health Professions
Essentials of Pharmacology for Health Professions
Nursing
ISBN:
9781305441620
Author:
WOODROW
Publisher:
Cengage
3-2-1 Code It
3-2-1 Code It
Biology
ISBN:
9781337660549
Author:
GREEN
Publisher:
Cengage
Principles Of Pharmacology Med Assist
Principles Of Pharmacology Med Assist
Biology
ISBN:
9781337512442
Author:
RICE
Publisher:
Cengage