1.2i. Describe the relationship between partitionconstant and partition ratio.ii. briefly discuss types of extraction methods usedin chemical analysis.iii. Briefly discuss the elution chromatography oncolumns (use a diagram to illustrate youranswer).

1. Partition Constant (K): The partition constant, often denoted as K, is a measure of the…

Answered: 1.2 i. Describe the relationship…

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter28: High-performance Liquid Chromatography

Section: Chapter Questions

Problem 28.3QAP

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The partition coefficient of caffeine between dichloromethane and water is 4.6. Given a 50 mL saturated solution of caffeine, determine the percent recovery of caffeine in a single extraction using 20 mL of DCM; and determine the percent recovery of caffeine when the extraction is done twice using two portions of 10 mL of DCM.
If the concentration in a bulk solution adjacent to a fibrous medium is at a concentration cA = 1mM, and partition coefficient of K = 0.7, what is the concentration in the %3D leading edge of the fibrous medium? the answer has units of mM (canvas does not allow you to enter units or display the answer with units.) your answer mM
6. ( If the solubility of solute Z is 1.0 g/60 mL in diethyl ether and is 1.0 g/1110 mL in water. a) Determine the partition coefficient for the solute Z in these two solvents. b) If 60 mg of the solute Z were dissolved in 100 mL of water, how much ether would be required to extract 90% of solute Z in a single extraction. c) What percent of the A would be extracted from the aqueous solution in (b) by two 50 mL portions of ether?
Solute A has a partition coefficient of 3 between toluene and water, with three times as much in the toluene phase. Suppose that 100 mL of a 0.010M aqueous solution of A is extracted with toluene. What fraction of A remains in the aqueous phase, if five extraction with 100 mL is performed?
A solution of 3g organic compound X in 200ml of water was extracted with 200 ml of ethyl ether. At equilibrium the concentration of Xin the two phases was ; 2.6g/100ml of ethyl ether ; 0.8g/100 ml of water. Calculate the partition coefficient, Kd, for compound X in the system. Show your calculations and What percentage of the original sample of X was extracted? Show your calculations.
The partition coefficient for caffeine between dichloromethane and water is 4.6. Assume that a 100 mL tea solution (in water) contained 100 mg of caffeine. What is the theoretical yield of caffeine in the methylene chloride if you extract with one 100 mL portion of methylene chloride?
What is the partition Coefficient of phenazopyridine? With illustration
The octanol-water partition coefficient can be used to determine how a chemical will distribute between an aqueous phase and a fatty tissue phase (based on the statement given above, is it true or false ?
Acetone has a partition coefficient of 13 while DCM has a partition coefficient of 4.6. Why is DCM used for the extraction of caffeine from Black teabags?
Two species A and B are known to have water/hexane partition coefficient of 5.99 and 6.16. They are separated by elution on silica gel with hexane as eluent. The ratio for the packing VS/VM =0.425a) What column length should be used to provide a resolution of 1.5 if the plate height ofthe packing is 1.5 ×10-3 cm? b) If the flow rate is 6.75 cm min-1, how long will it take to elute the two species?
A solute is added to a water- benzene mixture and mixture and shaken vigorously. 25ml benzene layer contains 0.1g solute and 25ml water layer contains 0.25g solute. What is the value of distribution coefficient or partition coefficient?
A. Water and chloroform has a partition coefficient of 5.00. A 50.00mL sample of a 8M aqueous solution of the solute is extracted with 10.00mL of chloroform. 1. What is the extraction efficiency for this separation? 2. What is the solute's final concentration in each phase? 3. What is the volume of chloroform needed to extract 99.00% of the solute? B. As described in Expt 2.A. determine 1. the extraction efficiency for 3 extractions and 2. the number of extractions required to ensure that 95.00% of the solute is extracted.

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1.2 i. Describe the relationship between partition constant and partition ratio. ii. briefly discuss types of extraction methods used in chemical analysis. iii. Briefly discuss the elution chromatography on columns (use a diagram to illustrate your answer).