1.The discovery step and the identification or consisting of the choice of the therapeutic target discovery and production of new active substances interacting with the selected target. • Choose a disease » Choose a drug target • Identify a bioassay » Find a 'lead compound' • Isolate and purify the lead compound if necessary • Determine the structure of the lead compound • Identify structure-activity relationships (SARS) • Identify the pharmacophore
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- What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? This under Bipharmaceurics and Pharmacokinetics subjectCompare and contrast the various drugs used in treating GERD and PUD. DRUG CLASS Proton pump inhibitors H2-R antagonists Antacids Cytoprotective Drugs •Misoprostol Rebamipide ADVANTAGES DISADVANTAGES (in pharmacological (Risks/SE/ADRs/DI) terms) •SucralfatePlease give me a discussion/explanation of ( TARGET SELECTION ) part in drug discovery and development.
- Explain the benefit of narrow spectrum over broadspectrum drugsPlease give me a discussion which include all aspects in drug discovery and development, from preclinical studies until clinical study.- Lead discovery- Target selection- Medicinal chemistry- In vitro studies- In vivo studies- Clinical studiesWhat are the different component of therapeutic index. Define its clinical relevance
- 1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…unt . oard ses B ps 1 dar 12 X 不 4 1 2 3 41 ry 5 79°F 6 N 26 1 point Theory X Q Caring x 4 e.com/courses/1437/external_tools/retrieve?display-full_width&url=https%3A%2F%2Fallsaintsuniver... ✰ 27:26 Time Remaining < Return Next The physician has ordered a large dose of intravenous opioids by continuous infusion. You know that one of the adverse effects of this medicine is respiratory depression. When you assess your patients respiratory status, you find that the rate has decreased from 16 breaths per minute to 10 breaths per minute. What action should you take? 0000 Stimulate the patient in order to increase respiratory rate. Allow the patient to rest comfortably. Report the decreased respiratory rate to the physician Decrease the rate of IV infusion Previous Q Search L 9 K P 0 Next 218 PM 4/1/2024Briefly discuss how we can improve pharmacodynamic properties of H1-Antihistamine drugs?
- Answer the following questions:1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product?2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product?3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)?4. How could the manufacturing process affect drug product performance?5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived?6. What is meant by “sink” conditions?7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration?8. For a lipid-soluble drug that has very poor aqueous solubility, what…Discuss three types of drug-drug interactions, and explain the links to pharmacodynamics and/or pharmacokinetics, with examples. Give the mechanims.Please answer it correctly for an Upvote. Thank you. •Give an antiseptic as an example and analyze the mechanism of action that results in its inhibiting effect.