2) a. In the synthesis of Camptothecin, a potent antitumor and antileukemic agent isolated from the stem wood of a Chinese Nyssaceae tree, the following conversion is made. Come up with a reasonable mechanism for the following conversion using proper electron pushing and reasonable chemistry. CHO NH₂ N-CO,Et -CO₂Et H H NaOH, aq EtOH R₂NH b. The following reaction is an example of Mannich reaction. Please write a reasonable mechanism. N H N-CO2Et CO,H R₂N H

2) a. In the synthesis of Camptothecin, a potent antitumor and antileukemic agent isolated from the stem wood of a Chinese Nyssaceae tree, the following conversion is made. Come up with a reasonable mechanism for the following conversion using proper electron pushing and reasonable chemistry. CHO NH₂ N-CO,Et -CO₂Et H H NaOH, aq EtOH R₂NH b. The following reaction is an example of Mannich reaction. Please write a reasonable mechanism. N H N-CO2Et CO,H R₂N H

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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