3. Regulation of cellular metabolism by insulin requires activation of the insulin-receptor substrate protein-1 (IRS1). Some individuals who have type 2 diabetes mellitus have mutations in the IRS1 gene. Which of the following normal steps in insulin signaling is most likely to be impaired by these mutations? A) Cleavage of IRS1 by the insulin receptor B) Phosphorylation of IRS1 by the insulin receptor C) Production of inositol 1,4,5-trisphosphate by IRS1 D) Stimulation of a G protein by IRS1 E) Synthesis of diacylglycerol by IRS1

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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3. Regulation of cellular metabolism by insulin requires activation of the insulin-receptor substrate protein-1 (IRS1).
Some individuals who have type 2 diabetes mellitus have mutations in the IRS1 gene. Which of the following normal
steps in insulin signaling is most likely to be impaired by these mutations?
OA) Cleavage of IRS1 by the insulin receptor
OB) Phosphorylation of IRS1 by the insulin receptor
OC) Production of inositol 1,4,5-trisphosphate by IRS1
D) Stimulation of a G protein by IRS1
E) Synthesis of diacylglycerol by IRS1
Transcribed Image Text:3. Regulation of cellular metabolism by insulin requires activation of the insulin-receptor substrate protein-1 (IRS1). Some individuals who have type 2 diabetes mellitus have mutations in the IRS1 gene. Which of the following normal steps in insulin signaling is most likely to be impaired by these mutations? OA) Cleavage of IRS1 by the insulin receptor OB) Phosphorylation of IRS1 by the insulin receptor OC) Production of inositol 1,4,5-trisphosphate by IRS1 D) Stimulation of a G protein by IRS1 E) Synthesis of diacylglycerol by IRS1
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