4. RNA hydrolysis As discussed in class, we can predict how much of RNA we expect to be in a reactive form using general chemistry calculations(Henderson Hasselbach). a) Calculate the percent of RNA at pH-8 that will have the 3'OH in its reactive alkoxide form (O-). The pKa of the 3'OH is approximately 13. b) Now redo the calculation to get the percent O-/OH at pH=6, and pH=10. c) What conditions favor more reactive RNA? How could we use a catalyst to enable more RNA to be in its reactive form?
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- IV D5W/NS with 20 mEq KCL 1,000 mL/8 hr Allopurinol 200 mg PO tid Fortaz 1 g IV q6h Aztreonam (Azactam) 2 g IV q12h Flagyl 500 mg IV q8h Acetaminophen two tablets q4h prn A.Calculate mL/hr to set the IV pump. B. Calculate how many tablets of allopurinol will be given PO. Supply: 100 mg/tablet. C. Calculate how many mL/hr to set the IV pump to infuse Fortaz. Supply: 1-g vial to be diluted 10 mL of sterile water and further diluted in 50 mL NS to infuse over 30 minutes. D. Calculate how many mL of aztreonam to draw from the vial. Supply: 2-g vial to be diluted with 10 mL of sterile water and further diluted in 100 mL NS to Infuse over 60 minutes. E. Calculate how many mL/hr to set the IV pump to infuse Flagyl. Supply: 500 mg/100 mL to infuse over 1 hour.SHoul WORSINGS 2 A one-wees old baby weighs 2250 grams. The order is For chloramphenizol g5ma v qub. The recommended dssage of chloramphenizol is 28 mg/kglday In tuio divided doses. 9) what is the recommended darty dosage for this Infant 3 b) what iS the recommended single dose for this Infanf? ) Is the dosage ordered safe?A physician order s Sentamycin 40mg lvqah fur a'child who The recommended do3age fur childrenis 3 - bmgl ) weighs 24 1bs. Kgl day In three divided doses . a what recummended minimum E maseimum daily dosages are the for this child ? b) what are the cmmended minimum single recor dosages fur this child? c) Is the ordered dosage safe ?
- Vancomycin homework gn nidiw.0od leeq mmitaco. 1. If the elimination rate constant is 0.250 hr-1, what is the percentage of drug removed per hour? 231 alomatblo 16ay 2 ilullao diw (al 2. L.C., a 45 year old male (5'10", 89 kg), is to begin Vancomycin (along with Zosyn and Levaquin) for broad-spectrum coverage for severe pneumonia. He is unstable and appears septic (serious) at this time. WBC=18.8, SCr=1.4 mg/dL.nmonen a. What is L.C.'s dosing body weight for Vancomycin? b. Calculate a loading dose for Vancomycin for L.C. Please round to the nearest 250mg c. Calculate L.C.'s creatinine clearance d. Estimate L.C.'s volume of distribution for Vancomycin 1891ew e. Estimate a Vancomycin maintenance dose and interval for L.C. Round to the nearest 250mg leve10:45 O O 0 .l.il 55 امتحان نصف السنة لمادة الطب الباطني ل لعام . . . During an oral examination of 1 point 65-year-old woman you noticed macroglossia and hoarseness of voice. On further questioning, the woman was complaining from excessive fatigue, weight gain, and cold intolerance. Her laboratory investigations show a high TSH level. This old woman has? Hyperthyroidism. Hypothyroidism. Hyperparathyroidism. Hypoparathyroidism. Thyroid cancer.The Order is for o)alacin C 30omg 9sh lv. The drug is available in a vial containing aml Ê labeled 900mg doses of o)alacin will youget frum this vial ? How many
- 2. 3. The doctor has ordered 60mg furosemide PO 12-hourly for Mrs. A. The furosemide tablets are labelled 20mg. How many tablets does Mrs. A receive in a day? Prozac stock is labelled 20mg/5mL. Mr. B is prescribed 40mg Prozac. How many mL will you give?... ix xii xjji 1 3 5 31 47 64 112 4. Order: Lactulose 30 g PO qid for hepatic encephalopathy How many mL will you give? NDC0054- 3486-68 10 g per 15 mL Indication and Dosage: For the treatment of constipation. See insert labeling for full information. Each 15 mL contains: 10 g lactulose (and less than 1.6 g galactose, less than 1.2 g lactose, 1.2 g or less of other sugars). Usual Dosage: 1 to 2 tablespoonfuls (15 to 30 mL) daily. Since lactulose does not exert its effect until it reaches the colon, and since transit time through the colon may be slow, 24 to 48 hours may be required to produce a normal bowel movement. Some patients have found that lactulose solution may be more acceptable when mixed with juice, water or milk. Pharmacist: When ordering this product, include the NDC number in the description. Dispense in tight, light-resistant container as defined in the USP/NF with a child-resistant closure. Store at Controlled Room Temperature 15-30°C (59-86°F). DO NOT FREEZE. Caution:…A 3YO 31lb child with edmena has been ordered furosemide 2mg/kg PO once daily. Furosemide oral solution is available in 60mL bottles containing 10mg/mL. How many mL will you administer each day?
- 18. Esmolol 1.2 g in 500 mL D5W has been ordered at a rate of 100 mcg/kg/min for a client weighting 103.2 kg. Determine the following: a) dosage in mcg/min: b) rate in mL/hr c) Is the dosage administered to the client safe?1&1/2 tsp po BID x 14 days #QS How many milliliters should the pharmacy dispense?1.Calculate the dose needed per session for the patient with a height 170.5 cm and is 200-lb based on the prescription PrescriptionRx Epirubicin 100 mg/m2 IV q21 daysCyatarabime 100mg/sq.meter/dose q12hr for 7days5-fluorouracil 500 mg/m2 q21 daysDexamethasone 10mg q24hMetoclopramide 4mg q24h QUESTION