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- 1. A prescription calls for 50 mg of chlorpheniramine maleate. Using a prescription balance with a sensitivity requirement of 6 mg, explain how you would obtain the required amount of chlorpheniramine maleate with an error not greater than 5%.4. On a TLC plate containing silica gel, which compound will have the largest Rf value when ethyl acetate is used as the mobile phase? Circle your answer for credit. Compound A CH3 cor CH3 H₂C COOH Compound B H.C. 0 CH,3. Astelin nasal spray contains 0.1% azelastine hydrochloride and 400 µg/mL of benzalkonium chloride as a preservative. A container is capable of delivering 200 metered sprays of 0.137 mL each. The percent concentration of benzalkonium chloride in the preparation is ________ %, and this is equivalent to a ratio strength of 1:2500 w/v. True or False?
- 2. Which of the following statements is true regarding steam sterilization? a. It is a universal technique, applicable to a product of any nature. b. At the same temperature, usually more effective than dry heat. c. Steam sterilization is amenable to a continuous workflow. d. The purpose of the steam is to keep the product from drying out during sterilization. Steam cannot be combined any other sterilization technique. е.4.Why is it important to include control groups and placebos in studies of the ergogenic properties of any substance or phenomenon?1. Calamine Lotion is classified as a suspension. What is a suspension? A. It is a disperse system in which solid, vehicle-insoluble particles (internal phase) are uniformlysuspended by mechanical agitation and formulation design throughout the liquid vehicle(external phase).B. It is a clear, flavored, sweetened, hydroalcoholic liquid oral preparation that usually containeither potent or unpleasant tasting drugsC. It is a concentrated aqueous solution containing one or more sugar components, chiefly sucrose,or sugar substituteD. It is a viscous oral liquid containing one or more medicament dissolved in a vehicle that usuallycontains high proportion of sucrose or other sugars.
- 1. In what proportion should alcohols of 95% and 50% strengths be mixed to make 70% alcohol? 2. A Hospital pharmacist wants to use three lots ZnO ointment containing repectively 50%, 20% and 5% ZnO. In what proportion should they be mixed to prepare a 10% ZnO ointment?&. How many milldiners of a 2wv Lidocaine HCI stock selution in water should be used in preparing 30 ml of a 0.5% wiv Lidocaine HCI solution? . From the following formula for antificial tears, caleulate the quantity of each ingrodient roquired to prepare half donen of the 0ml containers. Poyviny alcohol 149 Povidone Chiorobutanol Serile sodum chioride soution a.%. s to 100 m How many milldiners of water should be added to 60 ml. of a 2% wiv agqueous solution to prepare a 1% wiv solution?4. Why is 70% ethanol rather than pure ethanol preferred for use as an antiseptic agent? BARTLEBY
- 1. Given the following common laboratory materials, which of the three methods of heat sterilization do you think is the most appropriate and practical to use in sterilizing them Why do you think so ? Method of heat sterilization Reason a. Empty flasks b. L-rod (glass rod) c. 10 ml glass pipet d. Wire needles e. Antibiotic solution4. TLC is still useful in the lab but is being replaced by automated chromatographic methods. For example, TLC, FPLC, and HPLC are now automated processes, and computers can control various parameters, such as flow rate, blends of solvent mixtures, etc. Can you think of how the ability to manipulate the parameters of these automated chromatographic methods (sample size, column plate length, flow rate, solvent gradients, etc.) might accentuate or improve an investigator's ability to separate amino acids or other biomolecules?5. a) Thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) can be used asexamples to explain difference between adsorption and partition. For each of these chromatographic techniques,identify:+ the stationary and mobile phase+ how the mobile phase movesb) How is the Rf value for a spot on a TLC plate calculated? What can the Rf value be used for? In order toachieve the best separation of several components of different polarity in a mixture spotted on a TLC plate,what guideline should one follow regarding the choice of a developing solvent? (i.e. polar, non-polar, etc.)