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- (1) Discuss the structure and function of ion channels and describe their importance in medicinal chemistry. (ii) Draw the molecular structure of tamoxifen and discuss, in detail, its mode of therapeutic activity. Use the protein databank (PDB entry: 3ERT) to help support your answer.Explain using 2-3 sentences the biological significance of the following peptides. Ceruloplasmin Oxytocin1. Write the sequences of peptides that would be released from the following peptide by the treatment of trypsin? Heptadecapeptide Cortistatin DRMPCRNFFWKTFSSCK
- a) What is the secondary structure of the peptide hormone GLP-1?43. Sequentially list the signal transduction process from ligand binding to biological response for the phospholipase C system. You may use the appropriate abbreviations in your list.Unbranched homopolymer of N-acetyl glucosamine is : 1.Cellulose 2.Chitin 3.Curcumin 4.Concanavalin A
- H CH₂ H₂C HC-CH3 CH₂ H H₂C (S) H₂C H CH₂ CH₂ CH₂ NH O C NH NH₂ a) Which of the following statements about this peptide are correct? Group of answer choices Treatment of this peptide with trypsin generates two products. This peptide is a substrate for carboxypeptidase A Treatment of this peptide with cyanogen bromide generates a pentapeptide and a tripeptide. Treatment of this peptide with chymotrypsin generates three products. Treatment of this peptide with elastase generates 2 products. None of the above statements are correct. b) What is the sequence of this peptide using one letter abbreviations? c) What is the pH which would correspond to the ionization of the peptide as drawn above? 1, 5, 7, 10, 1411. Hydrophobic primary messengers usually cause molecular changes leading to modifications in metabolism. Examples of hydrophobic primary messengers are Explain what are their general chemical properties. A) thyroxine (tyrosine-derived hormone) and insulin (a small peptide hormone) B) the steroid hormones C) tyrosine-derived epinephrin and norepinephrin D) serotonin and melatonin (tryptophan-derived mammalian neurotransmitters) E) auxins (tryptophan-derived plant hormones) Answer: Explanation:please give full synthesis reaction of these drugs a) Cetirizine b) Loratadine