6.1 A physician asked you to recommend a loading dose and a constant rate IV infusion of a drug to rapidly achieve a steady-state concentration of 15 mg/L. The half-life of this drug is 6 h and the volume of distribution is 30 L. What is your recommendation?
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- 3a) An 68 kg patient is to be given a 2.0 mg/kg body weight IV bolus dose of a newly developed antibiotic drug every 6 hours. Assume the half-life of the drug and its volume of distribution in the patient are 3.2 hours and 0.26 L/kg respectively. (a) Calculate the peak and trough plasma concentrations for the antibiotic after, one dose, two doses, four doses, and at steady state.Treatment with the drug carvedilol for heart failure is initiated with a dose of3.125 mg twice daily and then increased every two weeks with twice-daily doses of6.25 mg, 12.5 mg, and 25 mg. How many of each of these tablet strengths shouldbe dispensed for this protocol?6, If Mr. Strong is admitted to the hospital and administered Buprenex, how much will you draw up in the syringe for a 0.6-mg dose? How many milliliters (mL) will be needed per day if the dosage range is 0.3 to 0.6 mg every 6 hours? (Buprenex 0.3 mg/mL.) Please show your calculations. nhohia Use the Internet to
- The biexponential equation for a two compartment model drug is C1,t = 50.0e-1.64t + 20.0e-0.147t. The drug is administered as a rapid IV bolus at t = 0. After 2.00 hours how many mg/l will the drug concentration in the central compartment be.One general guideline for the maintenance dosing of heparin in pediatric patients is 100 units/kg every4 hours, or 20,000 units/m²/24 hour administered continuously. The a vailable injection for use by intravenous infusion contains 1000 USP Heparin Units/mL For a 44-lb child, measuring 42 inches in height, calculate the difference between the quantities of heparin administered over a 24-hour period in (a) heparin units, (b) in milligrams of heparin (sod ium), and (c) in milliliters of heparin injection.To calculate the total amount of drug in a solution How much sodium bicarbonate is there in a 200 mL infusion sodium bicarbonate 8.4% w/v?
- a) The total amount excreted into urine as unchanged drug after an oral tablet (A) of 50 mg was 36.4 mg. After an oral capsule dose (B) of 25 mg the Uo was 20.3 mg. Calculate the relative bioavailability of the tablet A with respect to capsule B. If the absolute bioavailability of the oral capsule is determined to be 0.86 calculate the absolute bioavailability of the tablet dosage form. You are required to list the given data, formula and steps for calculationsA 100 ml vial of alteplase, a thrombolytic drug, contains 100 mg of drug equivalent to 58,000,000 international units to be administered via intravenous infusion. Determine the units administered to a patient who weighs 172 lb at a dose of 0.9 mg/kg and the volume of injection to use. 43,100,200 units: 78.60 mL 50,810,000 units: 75.50 mL O45,500,700 units: 73.80 mL 40,808,800 units: 70.40 mLHow many grams of dextrose are contained in a 250 ml intravenous infusion of a dextrose injection containing 60 g of dextrose per 100 ml, if it's specific gravity is 1.20?
- 49 A 1 litre infusion of sodium chloride 0.9% is being given at a rate of 28 drops/min (standard giving set). How long will the infusion run at the specified rate?Acute lymphatic leukemia can respond well to methotrexate given 2 1/2 mg per kilogram every 14 days by IV rounding to the nearest whole number. What would be the appropriate dosage of methotrexate to administer biweekly to a patient weighing 110 pounds?An IV infusion is to contain 40 mEq of potassium ion and 10 mEq of sodium ion in 500 mL of D5W.Using a 20% w/v potassium chloride injection (MW 74.5, valence of 1) and 0.45% sodium chlorideinjection (MW 58.5, valence of 1), how many milliliters of each should be added to the 500mL bag ofD5W to supply the required ions?