8. Patients on Irinotecan therapy increase production of hCES2 even though hCES2 breaks it down. (10.1093/jnci/div132) Knowing this, How would you think about determining the optimum dosage of both drugs (Irinotecan and Compound 24) in a patient with chronic diarrhea/ulcerative colitis that is being treated for colon cancer? (There are a lot of right answers here). (Remember, Irinotecan and Compound 24 are BOTH binding hCES2).
8. Patients on Irinotecan therapy increase production of hCES2 even though hCES2 breaks it down. (10.1093/jnci/div132) Knowing this, How would you think about determining the optimum dosage of both drugs (Irinotecan and Compound 24) in a patient with chronic diarrhea/ulcerative colitis that is being treated for colon cancer? (There are a lot of right answers here). (Remember, Irinotecan and Compound 24 are BOTH binding hCES2).
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Transcribed Image Text:8. Patients on Irinotecan therapy increase production of hCES2 even though hCES2 breaks it down.
(10.1093/inci/div132) Knowing this, How would you think about determining the optimum
dosage of both drugs (Irinotecan and Compound 24) in a patient with chronic
diarrhea/ulcerative colitis that is being treated for colon cancer? (There are a lot of right
answers here). (Remember, Irinotecan and Compound 24 are BOTH binding hCES2).
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