Answered: (A) (B) hs-Fz/+ hs-Fz/+ +/+ Dsh A/+…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question

The Wnt planar polarity signaling pathway nor-
mally ensures that each wing cell in Drosophila has a sin-
gle hair. Overexpression of the Frizzled gene from a heat-
shock promoter (hs-Fz) causes multiple hairs to grow from
many cells (Figure Q15–5A). This phenotype is suppressed
if hs-Fz is combined with a heterozygous deletion (DshΔ)
of the Dishevelled gene (Figure Q15–5B). Do these results
allow you to order the action of Frizzled and Dishevelled
in the signaling pathway? If so, what is the order? Explain
your reasoning

(A)
(B)
hs-Fz/+
hs-Fz/+
+/+
Dsh A/+
Figure Q15-5 Pattern of hair growth on wing cells in genetically
different Drosophila (Problem 15-17). (From C.G. Winter et al., Cell
105:81-91, 2001. With permission from Elsevier.)
3

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