== A Toxoplasma gondii mutant (shown below) was made by Hunter and Sibley. The mutant T. gondii had a truncated ROP18 gene which prevented ROP 18 from binding to the parasitophorous vacuole as shown in the figure below. What would you expect to see when a host mouse was infected with this mutant T. gondii? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b с Question 3 Homework Unanswered d e b Full-length ROP18 Prodomain Signal peptide Low-complexity basic regions Membrane targeting Catalytic domain ROP18 881 Nucleus Ser/The kinase T.gondi Truncated ROPIS ROPIS P The mutated ROP18 protein would bind with IRG proteins in the cytoplasm and neutralize the effects of IRG. Nature Reviews | Microbiology The mouse would have difficulty clearing the T. gondii infection due to the mutated ROP18 since the mutation would decrease the host's defenses against the parasite. The ROP18 mutation would have no effect on the host's ability to clear the T. gondii infection since ROP18 is not involved in parasitic defense. The mouse would clear the T. gondii infection more effectively since the parasitic defense protein is mutated and has an altered function. The mouse would clear the T. gondii infection more effectively since the ROP18 mutation increased the function of the host defense proteins.
== A Toxoplasma gondii mutant (shown below) was made by Hunter and Sibley. The mutant T. gondii had a truncated ROP18 gene which prevented ROP 18 from binding to the parasitophorous vacuole as shown in the figure below. What would you expect to see when a host mouse was infected with this mutant T. gondii? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b с Question 3 Homework Unanswered d e b Full-length ROP18 Prodomain Signal peptide Low-complexity basic regions Membrane targeting Catalytic domain ROP18 881 Nucleus Ser/The kinase T.gondi Truncated ROPIS ROPIS P The mutated ROP18 protein would bind with IRG proteins in the cytoplasm and neutralize the effects of IRG. Nature Reviews | Microbiology The mouse would have difficulty clearing the T. gondii infection due to the mutated ROP18 since the mutation would decrease the host's defenses against the parasite. The ROP18 mutation would have no effect on the host's ability to clear the T. gondii infection since ROP18 is not involved in parasitic defense. The mouse would clear the T. gondii infection more effectively since the parasitic defense protein is mutated and has an altered function. The mouse would clear the T. gondii infection more effectively since the ROP18 mutation increased the function of the host defense proteins.
Chapter16: Adult And Pediatric Dosages Based On Body Surface Area
Section: Chapter Questions
Problem 7.3P
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Transcribed Image Text:A Toxoplasma gondii mutant (shown below) was made by Hunter and
Sibley. The mutant T. gondii had a truncated ROP18 gene which prevented
ROP 18 from binding to the parasitophorous vacuole as shown in the figure
below. What would you expect to see when a host mouse was infected with
this mutant T. gondii?
Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer.
a
b
с
Question 3
Homework. Unanswered
d
e
b
Full-length ROP18
Prodomain,
Signal
peptide
N-
Low-complexity
basic regions
10
Membrane targeting Catalytic domain
ROP18 888
Nucleus
Ser/Thr kinase
87118
900
69
000
Ø
8888
T. gondii
C
C
Truncated ROP18
The mutated ROP18 protein would bind with IRG proteins in the cytoplasm and neutralize the effects of IRG.
N
ROP18
8
8
The mouse would have difficulty clearing the T. gondii infection due to the mutated ROP18 since the mutation would
decrease the host's defenses against the parasite.
88
The ROP18 mutation would have no effect on the host's ability to clear the T. gondii infection since ROP18 is not involved
in parasitic defense.
Nature Reviews | Microbiology
The mouse would clear the T. gondii infection more effectively since the parasitic defense protein is mutated and has an
altered function.
★
The mouse would clear the T. gondii infection more effectively since the ROP18 mutation increased the function of the
host defense proteins.
d
-C
ОР
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