Based on the above figure, which of the following issues are hearts with dilated cardiomyopathy likely to suffer? Options: impaired electrical conduction between cells impaired cell-cell communication poor cell-cell adhesion decreased energetic output from mitochondria impaired ability to pass mitochondria between cells

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter32: The Reception And Transmission Of Extracellular Information
Section: Chapter Questions
Problem 21P
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Please help me with this question. More than one answer may be correct. THe graph relating to the information is included below.

Dilated cardiomyopathy (DCM) is a condition in which the wall of the heart, starting with the left ventricle, stretches and thins.  This prevents the heart from pumping effectively and can be life threatening.  The above graph shows mRNA expression (left pane) and protein expression (right pane) for three molecular components of cardiomyocytes (GJA3 is the gene that encodes for Connexin 46, DSP is the gene that encodes for Desmoplakin, and CTNNA3 is the gene that encodes for Catenin α-3) between DCM cells and healthy cardiomyocytes (CNT). Based on the above figure, which of the following issues are hearts with dilated cardiomyopathy likely to suffer?

Options:

impaired electrical conduction between cells


impaired cell-cell communication


poor cell-cell adhesion


decreased energetic output from mitochondria


impaired ability to pass mitochondria between cells

A
mRNA relative expression level
120
100
80
60
40
20
0
T
T
***
T
GJA3
M
**
T
DSP
*
CTNNA3
DCM
CNT
B
Optical density (AU)
120
100
80
60
40
20
0
Connexin 46
Gapdh
***
T
47 KDa Desmoplakin
36 KDa
Connexin 46
Gapdh
*H
332 KDa
36 KDa
Desmoplakin
Catenin a-3
Gapdh
***
T
100 KDa
36 KDa
Catenin α-3
DCM
CNT
Transcribed Image Text:A mRNA relative expression level 120 100 80 60 40 20 0 T T *** T GJA3 M ** T DSP * CTNNA3 DCM CNT B Optical density (AU) 120 100 80 60 40 20 0 Connexin 46 Gapdh *** T 47 KDa Desmoplakin 36 KDa Connexin 46 Gapdh *H 332 KDa 36 KDa Desmoplakin Catenin a-3 Gapdh *** T 100 KDa 36 KDa Catenin α-3 DCM CNT
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