Based upon the following image of imatinib bound to BCR-ABL, which of the following mutations would result in the largest reduction in imatinib binding? Phe317 ☆ Tyr253 A. Phe317-Tyr B. Tyr253 Phe C. Thr315-lle D. lle313-Leu E. Phe359-Tyr Thr315 Phe382 Ile313 Met290 Glu286 Asp381 His361 Phe359
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- Some elongation factors are evolutionarily related to the G-proteins involved in signal transduction. Provide a possible reason why this is the case.Explain the signifi cance of the observation that peptides such as fMet-Leu-Phe “activate” the phagocytotic (particle-engulfi ng) functions of mammalian leukocytes (white blood cells).The codon change (Gly-12 to Val-12) in human rasH that convertsit to oncogenic rasH has been associated with many types ofcancers. For this reason, researchers would like to develop drugs toinhibit oncogenic rasH. Based on your understanding of the Rasprotein, what types of drugs might you develop? In other words,what would be the structure of the drugs, and how would theyinhibit Ras protein? How would you test the efficacy of the drugs?What might be some side effects?
- The distal Histidine (His 64) in myoglobin is subjected to three different mutations, this is one of them: H64N. (Histidine to Aparagine) For the mutation, draw a theoretical binding curve and CO relative to the O2 and CO binding curves for wild-type Mb (see example below). Provide a clear rationale for the binding curve.There was a study done (Isabel, et al.) on structural analysis of SARS-CoV-2 spike protein. The researchers hypothesized that a mutation in Asp 614 to Gly 614 will result in a loss of four inter-chain destabilizing (i.e., hydrophobic-hydrophilic) contacts. I attached an image that illustrates this (C). My question is: how does this classify as a repelling effect when Asp 614 should be hydrogen bonding with Thr 859? If Asp 614 is mutated to Gly 614, then wouldn't this hydrogen bonding no longer occur? Just not too sure what this hydrophobic-hydrophilic repelling effect is referring to exactly.These sequences are derived from the middle region of the covid-19 spike protein. Which choice or choices would not have m/z signature(s) that would allow them to be identified as tryptic peptide(s)? YNENGTITDAVDCALDPLSETK VDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEK RVQPTESIV
- What is the co-transduction index of histidine and tyrosine, standardized on tyrosine? Recipient Recipient leu- phe+ his- met+ tyr+ leu- phe+ his+ met- tyr+ leu- phe+ his+ met+ tyr- leu- phe- his+ met+ tyr+ leu+ phe+ his-met- tyr+ 127 leu+ phe-his-met+ tyr+ leu+ phe+ his+ met- tyr- leu+ phe-his+ met- tyr+ 0.017 leu- phe+ his+ met+ tyr+ leu+ phe+ his+ met+ tyr- 0.399 0.062 0.003 0.357 0.087 #wild type 37 138 132 1 leu+ phe+ his met+ tyr- 22 6 10 148 leu+ phe- his+ met+ tyr- 304 356 #wild type 31CTP synthetase catalyzes the glutamine-dependent conversion of UTP to CTP. The enzyme is allosterically inhibited by the product, CTP. Mammalian cells defective in this allosteric inhibition are found to have a complex phenotype: They require thymidine in the growth medium, they have unbalanced nucleotide pools, and they have an elevated spontaneous mutation rate. Explain the likely basis for these observations.GTP-y-s serves as an analog of GTP that cannot be hydrolyzed any further. How would a Co-IP experiment differ between G- alpha & G-beta proteins in the presence of GTP-y-a and GDP?
- From experiments in which cells expressing normal myosin II heavy chain were altered to either lack (mhckA-) or overexpress (MHCKA ++) a myosin heavy chain kinase (MHCKA). For answering this question recall the earlier the variants on the myosin II heavy chain, in which three key threonines, normally subject to reversible phosphorylation, were altered in various ways: 3X Ser = Serines in place of Threonines 3X Ala = Alanines in place of Threonines 3X Asp = Aspartate in place of Threonines MHCKA is present at normal levels. Which of the two mutants (mhcp- or MHCP++) would be most likely to have a defect in cytokinesis?Ribosomes markedly accelerate thehydrolysis of GTP bound to the complex of EF-Tu and aminoacyltRNA. What is the biological significance ofthis enhancement of GTPase activity by ribosomes?Would the following alterations to Src be oncogenic? Explain. (a) The deletion or inactivation of the SH3 domain. (b) The mutation of Tyr 416 to Phe.