Ch. 14-9 Mutations in the genes for clotting factor VIII and IX cause hemophilia A and B, respectively. A woman may be heterozygous for mutations in both genes, with a mutated factor VIII allele on one X chromosome, and a mutated factor IX allele on the other. All of her sons should have either hemophilia A or B. However, on rare occasions, one of these women gives birth to a son who does not have hemophilia, and his one X chromosome does not have either mutated allele. Explain.

Ch. 14-9 Mutations in the genes for clotting factor VIII and IX cause hemophilia A and B, respectively. A woman may be heterozygous for mutations in both genes, with a mutated factor VIII allele on one X chromosome, and a mutated factor IX allele on the other. All of her sons should have either hemophilia A or B. However, on rare occasions, one of these women gives birth to a son who does not have hemophilia, and his one X chromosome does not have either mutated allele. Explain.

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Description: Ch. 14-9Mutations in the genes for clotting factor VIII and IX cause hemophilia A and B, respectively. A woman may be heterozygous for mutations in both genes, with a mutated factor VIII allele on one X chromosome, and a mutated factor IX allele on t

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter28: Development And Inheritance

Section: Chapter Questions

Problem 43CTQ: Explain why it was essential that Mendel perform his crosses using a large sample size?

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Mutations in the genes for clotting factor VIII and IX cause hemophilia A and B, respectively. A woman may be heterozygous for mutations in both genes, with a mutated factor VIII allele on one X chromosome, and a mutated factor IX allele on the other. All of her sons should have either hemophilia A or B. However, on rare occasions, one of these women gives birth to a son who does not have hemophilia, and his one X chromosome does not have either mutated allele. Explain.
Hemophilia A is caused by a sex-linked recessive gene in human and in dogs. a. What proportions (and sexes), among their offspring will be hemophiliacs if a hemophilic male is mated to a homozygous nonhemophilic female?b. If a daughter produced by the mating in (a) is mated to a normal male, what proportions and (sexes) will be hemophilic among their offspring?
Ch. 14-4 Duchenne muscular dystrophy, which is inherited in an X-linked recessive pattern, nearly always occurs in males. Explain why.
Ch. 14-3 Marfan syndrome (Section 13.5) ) is inherited in an autosomal dominant pattern. What is the chance that a child will inherit the associated allele if one parent does not carry it and the other is heterozygous?
What is the Philadelphia chromosome? Briefly describe how it causes chronic myeloid leukemia.
Explain why it was essential that Mendel perform his crosses using a large sample size?
How can a female carrier of an X-linked recessive disorder have a daughter who is affected?
Ch. 13-7 Mutations in the TYR gene may render its enzyme product—tyrosinase—nonfunctional.Individuals homozygous for such mutations cannot make the pigment melanin. Albinism, the absence of melanin, results. Humans and many other organisms can have this phenotype (right). Mutated tyrosinase alleles are recessive when paired with the normal allele in heterozygous individuals.In the following situations, what are the probable genotypes of the father, the mother, and their children?a. Both parents have normal phenotypes; some of their children have the albino phenotype and others are unaffected.b. Both parents and children have the albino phenotype.c. The mother and three children are unaffected; the father and one child have the albino phenotype.
What is the significance of the Philadelphia chromosome, and how is it related to leukemia?
Imagine that individual V-8 marries a female cousin who is a carrier of the 5αRD mutation. What is the probability that they will have a child who has the disorder? answer should be a fraction.
Ch. 14-7 Expression of the SRY gene on the Y chromosome gives rise to the male phenotype in humans. What do you think the inheritance pattern of SRY alleles is called?
A female patient 19 years old, whose symptoms areanemia and internal bleeding due to a massive buildupof leukemic white blood cells, is diagnosed withchronic myelogenous leukemia (CML). Karyotypeanalysis shows that the leukemic cells of this patientare heterozygous for a reciprocal translocation involving chromosomes 9 and 22. However, none of thenormal, nonleukemic cells of this patient contain thetranslocation. Which of the following statements istrue and which is false?a. The translocation results in the inactivation (loss offunction) of a tumor-suppressor gene.b. The translocation results in the inactivation (loss offunction) of an oncogene.c. There is a 50% chance that any child of this patientwill have CML.d. This patient is a somatic mosaic in terms of thekaryotype.e. DNA extracted from leukemic cells of this patient,if taken up by normal mouse tissue culture cells,could potentially transform the mouse cells intocells capable of causing tumors.f. The normal function of the…