CHALLENGE QUESTION I: Smurf hemoglobin has a p50 of 30 torr and has 8 subunits, instead of the usual 4. It binds O2 with perfect positive cooperativity. What is the fractional saturation of Smurf hemoglobin at pO2=37 torr (the partial pressure on top of Smurf mountain)?
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- These are performance curves for two oxygen binding proteins. While we didn't go over the curves themselves in lecture, what are the axis labels? Myoglobin 0.8 0.6 V 0.4 0.2 I 0.0 25 50 1.0 Hemoglobin P50 = 26 torr 75 I 100 The y-axis is the fractional saturation of the protein by oxygen The x-axis is related to the concentration of oxygen to which the protein is exposed. The y-axis is the concentration of oxygen in the air. The x-axis is the fractional saturation of the protein by oxygenSelect the hemoglobin variant(s) that are described by each statement. (a) The variant least likely to cause pathological symptoms. (b) The variant(s) likely to show pl values different from that of HbA on an isoelectric focusing gel. (c) The variant most likely to show a decrease in BPG binding and an increase in the overall affinity of the hemoglobin for oxygen. Answer Bank Hb Milwaukee Hb Cowtown Hb Memphis Hb Philly Hb Providence Hb Bibba HbSO2-binding curves 1 0.9 0.8 2 0.7 3 0.6 0.5 0.4 0.3 0.2 0.1 100 120 20 40 60 80 po2 (torr) Fractional Saturation
- What is the total flow for a 35% venture mask set at 10 liters per minute at the flow meter?TOPIC: "Human Respiratory System" Differentiate the ventilation process between a normal person and a person suffering from COVID-19.Figure 5 shows oxyhemoglobin dissociatlon curves at pH 7.2 and pH 7.4. Which of the following is true at PO2 less than 40 mm Hg? 27. % saturation af haemogiobin 100 pH 7.4 80 60 pH 7.2 40 + 20 10 20 30 40 50 60 70 Po; (mm Hg) Figure 5 A. Hemoglobin retains less O2 at pH 7.4 compared to pH 7.2. B. Hemoglobin retains less O2 at pH 7.2 compared to pH 7.4. C. The release of O2 from hemoglobin is not influenced by the production of CO2. D. At pH 7.2 where CO2 production is less than pH 7.4, hemoglobin releases less O2.
- Q) Following an intensive course of chemotherapy, a 48-year-old woman had a thorough laboratory evaluation, selected results of which are: Hemoglobin 8 g/dL, hematocrit 32% Arterial blood gases: pH 7.38, Pa.CO₂ 42 mm Hg, bicarbonate 25 mEq/L, Pa.O2 62 mm Hg, O₂ saturation 92%. Given that the O2 binding capacity of hemoglobin is 1.34 ml/g, calculate the O2 capacity of her hemoglobin. A) 9.86 ml/dL B) 9.86 mm Hg C) 9.86 mEq/L D) 10.72 ml/dL E) 10.72 mEq/L Ans: D 6.11. Following an intensive course of chemotherapy, a 48-year-old woman had a thorough laboratory evaluation, selected results of which are: Hemoglobin 8 g/dL, hematocrit 32% Arterial blood gases: pH 7.38, Pa.CO₂ 42 mm Hg, bicarbonate 25 mEq/L, Pa.O₂ 64 mm Hg, O₂ saturation 92%. Given that the O2 binding capacity of hemoglobin is 1.34 ml/g, calculate the O2 content of her arterial hemoglobin. A) 9.86 ml/dL B) 9.86 mm Hg C) 9.86 mEq/L D) 10.72 ml/dL E) 10.72 mEq/L Ans: AWBC 5.6 Neutrophil 70% Calculate the Absolute Neutrophil Count?Hand written plz Q5/ Using lumped parameters model method find the following: 1- Sketch a network for the system shown in the figure? 2- Drive the losses equations. 3- What is the source of the resistance in the lungs? Figure (2) CO₂, other gases Air Lungs Circulatory system Body Kidneys Heart + Ingestion (food, drink) kut Excretion ndigested food) Excretion (urine)
- Hand written plz Q5/ Using lumped parameters model method find the following: 1- Sketch a network for the system shown in the figure? 2- Drive the losses equations. 3- What is the source of the resistance in the lungs? Ingestion (food, drink) Figure (2) CO₂ other gases Lungs Circulatory systems Kidney's S Heart Excretion (urine) Excretion ndigested food) BodyTrue or false? The plasma proteins suspended in blood cross the capillary cell membrane and enter the tissue fluid via facilitated diffusion. Explain your thinking.Calculate the duration of action assuming that the minimum effective concentration is 5mg/L 1000 100 y 400e0916 10 05 15 2. 2.5 Time (hours) Plasma concentration (me/)