CH₂OH OH OPO3-2 OH

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter6: Safe Dosage Calculations
Section: Chapter Questions
Problem A.9CRQ
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Will the amount of glycogen be higher or lower than normal or unchanged?

  1. Pyridoxal phosphate is covalently bonded to glycogen phosphorylase via a Schiff base to Lys 680. What effect would the mutation of Lys680Ala have on the breakdown of glycogen?(This notation means the following: K680 is the normal amino acid in this enzyme.  It has been mutated to 680A.) 
  2. Loss of the gene for the kinase that phosphorylates GSK3 on glycogen synthesis.
  3. Effect of the substrate analog below on glycogen synthesis.

 

CH₂OH
ОН
OPO3-2
OH
Transcribed Image Text:CH₂OH ОН OPO3-2 OH
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