Cyclic peptides received increasing amounts of attention because of their pharmaceutical propertie including interruption of protein-protein interactions. Please provide a mechanism for the synthesis of the cyclic peptide below from a prodrug protected linear peptide. (Amino acid R groups are simplified to A2, A3, ... as they are not participating in the reaction).
Cyclic peptides received increasing amounts of attention because of their pharmaceutical propertie including interruption of protein-protein interactions. Please provide a mechanism for the synthesis of the cyclic peptide below from a prodrug protected linear peptide. (Amino acid R groups are simplified to A2, A3, ... as they are not participating in the reaction).
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter3: Stereoisomerism And Chirality
Section3.8: The Significance Of Chirality In The Biological World
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