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- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)Nernst (equilibrium) Potential (mV) - 6.lol 0.07 0.125 D.094 lon Intracellular Extracellular Concentration (mM) Concentration (mM) K* 155 4 Nat 12 145 Ca** 104 1.5 4 120 D) If during the generation of an action potential in the skeletal muscle cell the membrane potential approaches +65 mV, membrane permeability for which ion likely plays a major role in membrane depolarization? Explain your choice.Define electrochemical gradients and the term “polarized”, and describe the electrochemical basis of the resting membrane potential including the function of the sodium-potassium pump in maintaining the resting membrane potential.
- At the peak of the action potential, Vm is approximately -65 mV. Assuming normal intracellular and extracellular K+ concentrations (refer to the table), (1) calculate the driving force (in mV) that acts on K+ ions and (2) use the information obtained in part 1 to determine the direction in which K+ ions will flow (i.e., into the cell or out of cell)Graph of membrane potential versus time The graph above represent time in milliseconds. At what time (in milliseconds) is the inside of the neuron the most positive and why? Explain why the membrane potential changes at X. Explain what is happening at point C to the sodium and potassium ions and how this is affecting the membrane potential. Describe two things that contribute to the resting membrane potential.Action potential +40 55 Threshold Falled initiations Resting state -70 Stimulus 1 Refractory period Time (ms) At the peak of the action potential, which of the following are true? Select all that apply the membrane potential is close to but less that the K+ equilibrium potential |voltage gated K+ channels close voltage gated K+ channels open the membrane potential is close to but less that the Na+ equilibrium potential Voltage (mV) Depolarization Repolarization
- Define resting membrane potential and describe its electrochemical basis. Briefly discuss changes to resting membrane potential. Provide specific examples of how the 4 essential concepts relative to resting membrane potential or disruption of resting membrane potential.What is the expected resting membrane potential (in mV) of a neuron that is typical in all ways except for possessing an extracellular potassium concentration of 104.3 mM, an intracellular sodium concentration of 103.6 mM, and 4 times the normal resting permeability to sodium?Myasthenia gravis is a disease that leads to a marked decrease in the number of acetylcholine (Ach) receptors at the neuromuscular junction. As a result, suppose only about 200 (instead of 2000) Ach receptor-channels are opened by each quantum of Ach. The Ach-gated channels that survive operate normally and each cause a depolarization of about 0.25 x 10-3 mV when open. The function of the presynaptic terminal is normal and an action potential will cause the release of 100 quanta of neurotransmitter. For a patient with myasthenia gravis, what would be the magnitude of the depolarization (in mV) associated with opening of one Ach-gated channel? a.) 0.25x10^-2 mv b.) 0.25x10^-3 mv c.) 0.25x10^-4 mv d.) 0.5x10^-1 mv e.) 0.5 mv
- Myasthenia gravis is a disease that leads to a marked decrease in the number of acetylcholine (Ach) receptors at the neuromuscular junction. As a result, suppose only about 200 (instead of 2000) Ach receptor-channels are opened by each quantum of Ach. The Ach-gated channels that survive operate normally and each cause a depolarization of about 0.25 x 10-3 mV when open. The function of the presynaptic terminal is normal and an action potential will cause the release of 100 quanta of neurotransmitter. Part a.) For a patient with myasthenia gravis, what would be the size (in mV) of a miniature excitatory post-synaptic potential (or that associated with one quantum of Ach)? a.) 0.05 mv b.) 0.25x10-4 mv c.) 0.25x10-3 mv d.) 0.5x10-3 mv e.) 0.5 mv Part b.) For a patient with myasthenia gravis, what would be the size (in mV) of the full excitatory post synaptic potential consequent to the entry of an action potential into the presynaptic terminal of the neuromuscular junction? a.) 70 mv…Summarize neuron communication from the moment of receptor stimulation to the response of an effector, such as a muscle fiber, and define neurotransmitter, resting membrane potential, and current. Define electrochemical gradients and the term “polarized”, and describe the electrochemical basis of the resting membrane potential including the function of the sodium-potassium pump in maintaining the resting membrane potential. Describe graded potentials including hyperpolarizing and depolarizing graded potentials. Describe action potentials (nerve impulses) including: Thresholds All-or-none principle Phases of action potential generation Refractory periodWhat is the equilibrium membrane potential due to Na+ ions if the extracellular concentration of Na+ ions is 154 mM and the intracellular concentration of Na+ ions is 27 mM at 20 ∘C ? Please answer asap and in short and content should not be palgarised please