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Discuss the advantages and disadvantages of general chemotherapy like Etoposide compared to specific inhibition of EGFR.
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- describe the outcome of EGFR inhibition as well as the differences between erlotinib and panitumumab’s mechanisms of action. EGFR- driven cancer cells can become resistant to tyrosine kinase inhibitors. Explain the two types of EGFR blockade acquired resistance and propose a subsequent treatment option.discuss the advantages and challenges involved in highly active antiretroviral therapy.Are there foods that contain natural inhibitors of MDRs (or P-gp) that can enhance effectiveness of chemotherapy or other pharmacotherapies?.
- Distinguish between What is known of CD105 (endoglin) as an hepatcellular carcinoma marker and it’s potential as a drug target. Discuss: - Is anything known about its biology? E.g does it have known ligands and normal functions? - if you were to target it would you just use it to get growth inhibiting compound into the new blood vessels or is CD105 required for neovascularization?Suggest how treating cancers using monoclonalantibodies could cause fewer side-effects thantreating them using conventional anti-cancerdrugs or radiotherapy.propose a biomaterial-based drug delivery system for carrying targeted delivery of doxorubicin for the specific treatment of hepatocellular carcinoma via intravenous route (for human)
- Discuss the challenges to producing anticancer drugsthat counteract the effects of mutations in tumorsuppressor genesGive examples and brief descriptions of pharmaceutical agents that work by altering responses in the RAS pathway.How we can improve pharmacokinetic parameters for the development of H1-Antihistamine ? Discuss
- Venurafenib Select one: a. Was developed as a treatment of Gleevec-resistant CML patients b. Inhibits MEK in some melanoma patients c. Melanoma patients with a V600E mutation became resistant to this treatment o d. Inhibits RASMrs. Anderson, a 45-year-old woman with a history of chronic back pain, has been taking X as prescribed by her rheumatologist for the past eight months. During a routine check-up, her liver function tests revealed significantly elevated liver enzymes. She has not experienced any noticeable symptoms but is now being closely monitored for potential liver-related issues. 2. Propose a pharmacoepidemiological study design to confirm or refute the signal of hepatotoxicity associated with X. Consider factors such as study population, exposure definition, and outcome measures. Discuss the strengths and limitations of your chosen study design? Outline the methods and data sources that could be used to collect information on hepatotoxicity in patients using X.? Discuss how the findings of the study could have regulatory implications. If a significant association is identified, explore how regulatory agencies might implement other measures to ensure patient safety.? Develop communication…Why is there caution against prescribing imatinib with strong CYP3A4 inhibitors?