DNA primase RNA primer DNA ligase DNA Polymerase (Pola), 3' Lagging strand Okazaki fragment 5' Leading strand Topoisomerase 3' DNA Polymerase (Pol8) Helicase Single strand, Binding proteins

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter28: Dna Metabolism: Replication, Recombination, And Repair
Section: Chapter Questions
Problem 11P
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The diagram shows a model of DNA replication. The diagram points out a number of enzymes and protein factors involved in the process. If this cell were cancerous, a doctor might be using a chemotherapy drug to prevent the replication process from taking place. One such drug, topotecan, inhibits the topoisomerase enzyme from working. Based on the model, if topotecan is used, how will this affect the replication process? A: The hydrogen bonds between the bases will not break B: The double helix of the DNA molecule will not unwind C: It will prevent the addition if complementary nitrogen bases to the leading or lagging DNA strands D: It will prevent the addition of nitrogen bases due to instability of the single-stranded DNA chains
DNA primase
RNA primer
DNA ligase
DNA Polymerase (Pola),
3'
Lagging
strand
3'
5'
Okazaki fragment
5'
Leading
strand
Topoisomerase
3'
DNA Polymerase (Polo)
Helicase
Single strand,
Binding proteins
Transcribed Image Text:DNA primase RNA primer DNA ligase DNA Polymerase (Pola), 3' Lagging strand 3' 5' Okazaki fragment 5' Leading strand Topoisomerase 3' DNA Polymerase (Polo) Helicase Single strand, Binding proteins
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