For S phase to be completed in a timely manner, DNA replication must be initiated from multiple origins in eukary-otes. In S. cerevisiae, what role do S phase CDKs and DDKs play to ensure that the entire genome is replicated once andonly once per cell cycle?
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For S phase to be completed in a timely manner,
replication must be initiated from multiple origins in eukary-
otes. In S. cerevisiae, what role do S phase CDKs and DDKs
play to ensure that the entire genome is replicated once and
only once per cell cycle?
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- Kinetochores control the transition from metaphase to anaphase. Why is this statement true? Question 7 options: a) Anaphase will only begin after the M checkpoint where all the kinetochores and mitotic spindle have correctly attached. b) Anaphase will only begin after the M checkpoint where all the mitotic spindle have correctly formed. c) Kinetochores bind to microtubules in monotelic attachment to the sister chromatids. d) Kinetochores bind to microtubules in syntelic attachment to the sister chromatids. e) Kinetochores will halt at the M checkpoint to weaken the mitotic spindle formation, which is the event that initiates anaphase.The oncogenic protein BETA promotes entry into the S phase of the cell cycle. Phosphorylation of BETA at the amino acid Tyr98 causes BETA to be degraded by the proteasome, thus limiting its abundance. A mutation in the codon encoding Tyr98 changes this residue to Cys, which cannot be phosphorylated. What is the best description of this mutant allele?a) antimorphb) hypermorphc) hypomorphd) amorphe) neomorphThe Yellow Fever vector mosquito (Aedes Aegypti) is normally 2n = 8. Please draw the following diagrams and in each of your diagrams label the following (or note the absence of): a) a pair of homologous chromosomes b) a pair of sister chromatids A) A somatic cell in this organism undergoing prophase. B) A germ cell undergoing anaphase II.
- How do the linear chromosomes in eukaryotes ensure that its ends are replicated completely?If you expose a culture of human cells (for example,HeLa cells) to 3H-thymidine during S phase, howwould the radioactivity be distributed over a pair ofhomologous chromosomes at metaphase? Would theradioactivity be in (a) one chromatid of one homolog,(b) both chromatids of one homolog, (c) one chromatid each of both homologs, (d) both chromatids ofboth homologs, or (e) some other pattern? Choose thecorrect answer and explain your reasoning.Antibiotics such as chloramphenicol, tetracycline, and erythromycin inhibit protein synthesis in bacteria, but have no effect on the synthesis of proteins encoded by eukaryotic nuclear genes. Cycloheximide inhibits the synthesis of proteins encoded by nuclear genes, but has no effect on bacterial protein synthesis. How might these compounds be used to determine which proteins are encoded by mitochondrial and chloroplast genomes?
- The molecular mechanism of SCE is similar to homologousrecombination between homologs except that the two segmentsof DNA are sister chromatids instead of homologous chromatids.If branch migration occurs during SCE, will a heteroduplex beformed? Explain why or why not. Can gene conversion occurduring sister chromatid exchange?To identify genes controlling the cell cycle in budding yeast, a genetic screen was carried out. In this screen, haploid yeast cells were exposed to a DNA damaging agent to introduce random mutations in the genome. By culturing cells at an elevated temperature (e.g. 37 degrees), where many mutated genes lose their function, scientists identified yeast mutants that showed growth defects and arrest at specific stages of the cell cycle (e.g. in mitosis with large buds). In this screen, mutants of the cyclin-dependent kinase were identified, but not mutants of cyclins. Explain the reason for this outcome.What molecular mechanism seems to be responsible for the movement of the poles during anaphase?
- If DnaA was not regulated in Escherichia coli and multiplerounds of replication were completed before cell division,what would be the consequence to the daughter cell and why?Would the resulting cell still be considered haploid?Discuss how ultra violet light works as a mutagen. This could include: What is UV light and the Mutations commonly introduced by UV light? What are the Repair mechanisms in yeast that fix damage caused by UV light? Describe the phenotypes of Saccharomyces Cerevisiae plates, the first plate is the control yeast, while the second plate has been exposed to low UV light, the third plate has been exposed to high UV light. Normal yeast has round smooth white colonies. Are there any signinifcant differences?The genome of D. melanogaster consists of approximately 1.7 * 108 base pairs. DNA synthesis occurs at a rate of 30 base pairs per second. In the early embryo, the entire genome is replicated in five minutes. How many bidirectional origins of synthesis are required to accomplish this feat?