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- Protease enzymes cleave proteins by hydrolyzing peptide bonds. The strategy for each type of metalloprotease begins with generating a nucleophile that attacks the peptide bond that attacks the peptide carbonyl group. O Macmillan Learning On the basis of the information provided in the figure, show the next step in the mechanism for peptide-bond cleavage by a metalloprotease. Metalloproteases H R₁ HN Zn Enz 2+ R₂ Draw curved arrows on the pre-drawn structures to show the metalloprotease mechanism. If you need to reset the structures, click More followed by Reset Drawing. Select Draw Templates Groups More B - H Enz H H с R1 | : HN O | Zn 2+ B R2 N Zn EraseLefer to the figure showing the molecular structure of dimethylmercury. H–C-Hg C-H H. Exposure of human skin to a single drop of dimethylmercury can lead to death, as it is highly poisonous and passes easily cell membranes. Based on its structure, why is it able to pass so easily through cell membranes? I-0-I IICIHStructures PLEASE DRAW OUT THE FATTY ACIDS - Hydrocarbon chain atoms DO NOT need to be labeled, everything else does. Common name Symbol Lauric acid 12:0 Myristic acid 14:0 Palmitic acid 16:0 Stearic acid 18:0 Arachidic acid 20:0 Palmitioleic acid 16:1 △9 Oleic acid 18:1 △9 Linoleic acid 18:2 △9,12 a-Linolenic acid 18:3 △9,12,15 g-Linolenic acid 18:3 △6,9,12 Arachidonic acid 20:4 △5,8,11,14
- Review I Constants I Periodic Table Part A A decapeptide undergoes partial hydrolysis to give peptides whose amino acid compositions are shown. Reaction of the intact decapeptide with Edman's reagent releases PTH-Gy. What is the sequence of the decapeptide? 1. Ala, Trp 2. Val, Pro, Asp 3. Pro, Val 4. Ala, Glu 5. Trp, Ala, Arg 6. Arg. Gly 7. Glu, Ala, Leu 8. Met, Pro. Leu, Glu Spell out the name of the polypeptide using three letter codes for each amino acid separated with hyphens (for example, Tyr-Lys-Trp). Submit Rleauest AnswerWhich of the following is true regarding Glycogen Linear homopolysaccharide O Contains beta-1 to 4 bonds O It has alph-helical structure O Energy storage heteropolysaccharide O Branched heteropolysaccharideFeature Ceulose Collagen Fibrous Monomers joined by condensation reactions Monomers identical Branching Describe the differeni between hydrophobic and hyrophilic using phospholipid molecues as an example
- e. Glycosidic linkage between ß glucose The main chemical structure difference between ribonucleic acid and deoxyribonucleic acid is in the ribose sugar carbon number Answer: on Next page age FUJITSU4- Salicylamides are inhibitors for an enzyme called scytalone dehydratase. SAR shows that there are three important hydrogen bonding interactions. Explain whether you think quinazolines could act as a bioisostere for salicylamides. HBA OH O 00 N NHR Quinazolines Salicylamides Ph HBA 5- Structure IX (X = NH) is an inhibitor of a metalloenzyme called thermolysin and forms interactions as shown. Explain why the analogue (X = O) has reduced binding affinity by a factor of 1000 and why the analogue (X = SH) has roughly the same binding affinity. Structure IX H HBD Ala-113 RMatch the following Class of Proteins with their corresponding Prosthetic Group Components. nucleic acids 1. hemoproteins metal ion 2. lipoproteins phosphate group 3. flavoproteins pigment 4. glycoproteins heme unit 5. phosphoproteins 6. nucleoproteins lipid 5. metalloproteins flavin nucleotides -8 chromoprotein carbohydrate
- Sphingolipids can contain of all of the following except O Glycerol O more than one choice O phosphate O a mono- or oligosaccharide O sphingosine.Draw the amino acid product that results from a transamination reaction involving pyruvate and glutamate, shown in the image below. Draw the product as it would occur at the pH of most body fluids, including all charges. You do not need to draw the other product of the reaction. O NH3 3D CH3-C-C-o-+ 0-CH-CH CH2-C-0--→? pyruvate glutamate Draw the molecule on the canvas by choosing buttons from the Tools (for bonds), Atoms, and Advanced Template toolbars. The single bond is active by default. Include all hydrogen atoms and charges. > View Available Hint(s) CONT. H. N. NV CI Br 1] -C- C1 SISphingolipid Ceramide Function Name and Structure of Attached Molecule Sphingomyelin Ganglioside