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Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
How is the ribosome a target in terms of antibiotic action mechanisms?
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- What is the major difference between bacterial ribosomes and eukaryotic ribosomes that makes it possible to target bacterial ribosomes without harming our own cells?The ribosome is the target for many important antibiotics. These drugs must discriminate between bacterial and eukaryotic ribosomes to achieve drug specificity and toxicity. For the two common antibiotics below, what is their mechanism of action and why are they more toxic to bacteria than eukaryotes? a) Tetracycline b) ErythromycinMatch the following antibiotics with the drug strategy that would provide resistance to them. rifampin which blocks transcription [ Choose ] Choose] tetracycline which misaligns the beta-lactamase anticodon to its codon mutation of the TRNA binding site of the ribosome penicillin which blocks peptidoglycan creation of alternate metabolic pathway that ultimately leads to the same product synthesis mutation of RNA polymerase polymyxin which causes leakage in the porin which removes drug from periplasmic space cell membrane sulfonamide which inhibits enzyme of [Choose ] folic acid synthesis pathway Question 14 2 pts % & 5 7
- What is the purpose for generating the riboprobe? What will it be used for in the lab?Bacillus subtilis is known to harbour proA gene which is expressed as protease. Protease is an industrially important enzyme but the yield from Bacillus is not satisfactory. What processes of genetic engineering can you conduct to increase the production of proA gene? Briefly discuss your vision on the context.Which letter represents the target site of furosemide (Lasix)? E- -B
- Describe the molecule shown in the image. Evaluation at Atomic Resolution of the Role of Strain in Destabilizing the Temperature Sensitive T4 Lysozyme Mutant Arg96-->HisLinezolid is a new type of antibiotic that inhibits protein synthesis in several bacterial species by bindingto the 50S subunit of the ribosome and inhibiting its ability to participate in the formation of translationalinitiation complexes. Physicians are particularlyinterested in this antibiotic for treating pneumoniacaused by penicillin-resistant Streptococcus pneumoniae (also called pneumococci). To explore themechanisms by which pneumococci can developresistance to linezolid, you first want to identifylinezolid-resistant strains. Next, using one of thesestrains as starting material, you want to identifyderivatives of these mutants that are no longertolerant of linezolid.a. Outline the techniques you would use to identifylinezolid-resistant mutant pneumococci andlinezolid-sensitive derivatives of these mutants.In each case, would your techniques involve directselection, screening, replica plating, treating withmutagens, or testing for a visible phenotype?b. Suggest possible…Translation in eukaryotes and prokaryotes are similar and yet different. From a therapeutic perspective, why is this advantageous?