How might you change the warfarin dosing strategy for a patient that had a variant in CYP2C9 that was LESS active than the reference/common allele? Assume they have no other variants in other genes that influence this pathway. Lower dose than the standard No change in the dose Higher dose than the standard There is no way to determine (this is not the answer, by the way)

How might you change the warfarin dosing strategy for a patient that had a variant in CYP2C9 that was LESS active than the reference/common allele? Assume they have no other variants in other genes that influence this pathway. Lower dose than the standard No change in the dose Higher dose than the standard There is no way to determine (this is not the answer, by the way)

Biology Today and Tomorrow without Physiology (MindTap Course List)

5th Edition

ISBN:9781305117396

Author:Cecie Starr, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Christine Evers, Lisa Starr

Chapter10: Biotechnology

Section: Chapter Questions

Problem 3DID

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Correct answers already provided! Please don't just tell me the answers bc I know them already. Help me with my own question. I get everything else in this problem other than the third option: Introduce the mutant human HD allele as a transgene into the mouse genome with transgene integration anywhere in the mouse genome. Why is the first question (left) okay with introducing mutant human HD allele and the second question (right) is not? I heard that introducing allele without using CRISPR-Cas9 is very rare and difficult. If so, how does it work in the first problem (Hungtinton's chorea)?
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