In the Fischer esterification reaction below, which best describes the first step of the mechanism? H3C s OH + CH3OH H3O+ H3C OCH3 + H₂O The alcohol oxygen acts as a nucleophile and attacks the proton of the acid. The alcohol oxygen acts as an electrophile and is attacked by the proton of the acid. The carbonyl oxygen acts as a nucleophile and attacks the proton of the acid. The carbonyl oxygen acts as an electrophile and is attacked by the proton of the

Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter19: Aldehydes And Ketones: Nucleophilic Addition Reactions
Section19.SE: Something Extra
Problem 28VC
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In the Fischer esterification reaction below, which best describes the first step of the
mechanism?
H3C
OH
+ CH3OH
H3O+
H3C
OCH3
+ H₂O
The alcohol oxygen acts as a nucleophile and attacks the proton of the acid.
The alcohol oxygen acts as an electrophile and is attacked by the proton of the
acid.
The carbonyl oxygen acts as a nucleophile and attacks the proton of the acid.
The carbonyl oxygen acts as an electrophile and is attacked by the proton of the
acid.
Transcribed Image Text:In the Fischer esterification reaction below, which best describes the first step of the mechanism? H3C OH + CH3OH H3O+ H3C OCH3 + H₂O The alcohol oxygen acts as a nucleophile and attacks the proton of the acid. The alcohol oxygen acts as an electrophile and is attacked by the proton of the acid. The carbonyl oxygen acts as a nucleophile and attacks the proton of the acid. The carbonyl oxygen acts as an electrophile and is attacked by the proton of the acid.
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