LI2CO3 LIBr DMF LDA CH,I Br2 THE в CH;CO,H a-methylene- ybutyrolactone

Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter31: Immunochemistry
Section: Chapter Questions
Problem 31.75P
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Identify A, B, and C, intermediates in the synthesis of the five-membered ring called an α- methylene-γ-butyrolactone. This heterocyclic ring system is present in some antitumor agents.

LI2CO3
LIBr
DMF
LDA
CH,I
Br2
THE
в
CH;CO,H
a-methylene-
ybutyrolactone
Transcribed Image Text:LI2CO3 LIBr DMF LDA CH,I Br2 THE в CH;CO,H a-methylene- ybutyrolactone
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