A1 OH H4. Pseudoephedrine (Sudafed, PSE) is a sympathomimetic drug ofthe phenethylamine and amphetamine chemical classes. It maybe used as a nasal/sinus decongestant, as a stimulant, or asa wakefulness-promoting agent in higher doses. Given thestructure of PSE (right):a. Draw a Newman projection that results from viewing downC1-C2, as indicated by the arrow. (6)b.c.Draw the highest energy Newman projection and comment on what makes thisconformation thermodynamically unstable relative to other conformations. (5)Consult the lowest energy conformation about the C1-C2 bond axis to postulate akey IMF that helps to stabilize the lowest energy conformation. Indicate this IMF onyour Newman projection in part (a). (5)

Here we have to write the highest energy and lowest energy Newman conformation of the following…

OH H 4. Pseudoephedrine (Sudafed, PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses. Given the structure of PSE (right): a. Draw a Newman projection that results from viewing down C1-C2, as indicated by the arrow. (6) b. Draw the highest energy Newman projection and comment on what makes this conformation thermodynamically unstable relative to other conformations. (5) Consult the lowest energy conformation about the C1-C2 bond axis to postulate a key IMF that helps to stabilize the lowest energy conformation. Indicate this IMF on your Newman projection in part (a). (5) c.

OH H 4. Pseudoephedrine (Sudafed, PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses. Given the structure of PSE (right): a. Draw a Newman projection that results from viewing down C1-C2, as indicated by the arrow. (6) b. Draw the highest energy Newman projection and comment on what makes this conformation thermodynamically unstable relative to other conformations. (5) Consult the lowest energy conformation about the C1-C2 bond axis to postulate a key IMF that helps to stabilize the lowest energy conformation. Indicate this IMF on your Newman projection in part (a). (5) c.

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter6: Alkanes & Alkenes

Section: Chapter Questions

Problem 5CTQ

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