Q: What is the position and orientation of TAR important for HIV-1 transcription?
A: Human immunodeficiency virus (HIV) - 1 proviral DNA transcription is done by Pol II of the host. It…
Q: Proline has a low frequency of occurrence in B-sheets, why?
A: Introduction: One of the 20 amino acids includes proline that is also known as imino acid as it…
Q: Why are protease inhibitors an effective treatment forhuman AIDS?
A: HIV is a member of retrovirus family that is closely related to SIV (Simian Immunodeficiency virus)…
Q: Besides being a general base, what's the other function of Asp in mechanism of HIV-1 aspartate…
A: HIV-1 Aspartate Protease is a retropepsin enzyme i.e., retroviral aspartyl protease enzyme. Besides…
Q: write the detail explation of mode of action of vincristine in detail . write the detail explation…
A: The mitotic cell cycle is constituted of the G1 phase, S phase,G2 phase and M phase. The microtubule…
Q: Would you expect actinomycin D to be a competitive inhibitor of RNA polymerase? What about…
A: A drug is a chemical substance that is used to treat any pathogenic, physiological or psychological…
Q: Give an example of a nucleoside analogue that has been used successfully as an antiretroviral drug.…
A: Nucleoside analogue can be defined as a class of drugs ,which are mainly used to as antiviral agent…
Q: fill in DNA antisensestrand for this
A: The coding strand or the sense strand is the double stranded DNA that carries the coding nucleotide…
Q: What does the enzyme reverse transcriptase do and why is it agood target for anti-HIV drugs?
A: A virus is a submicroscopic infectious agent. It replicates only inside the living cells of an…
Q: Using the substrate Ac-Ser-Gln-Asn-Tyr*Pro-Val-Val-NH2 and 10 nM HIV-1 protease, an inhibitor showed…
A: Michaelis-Menten mechanism is a rate equation that is applicable for a single substrate enzyme…
Q: What mechanism of antibiotic resistance does the NDM gene code for?
A: Antibiotic Resistance is the phenomenon by which any bacteria can survive in the presence of…
Q: How can one confirm/investigate the type of inhibition exerted by azt on the hiv reverse…
A: 3'-azido-3'-deoxythymidine (AZT) is a Thymine analogue. It inhibits HIV reverse transcriptase by…
Q: Why are single-stranded binding (SSB) proteins required?
A: SSBs are nucleoproteins that can be found in bacteria, bacteria, and animals. When opposed to…
Q: How is AZT a competitive inhibitor of HIV reverse transcriptase?
A: A vital early stage in the HIV life cycle is the reverse transcription of the viral RNA genome into…
Q: Because penicillin prevents peptidoglycan synthesis, it is more effective on cells.
A: In this question, effect of penicillin on the cell wall of different types of bacteria is to be…
Q: what is the purpose of arabinose for the gfp gene?
A: Arabinose is a constituent of many biopolymers that make up the plant cell walls.it is a…
Q: 2',3'-Dideoxyinosine has been approved as an anti-HIV drug' Propose a mechanism by which it might…
A: Human Immuno Deficiency virus, and the treatment.
Q: Why are proteins synthesized from Spirulina called Single celled Proteins? What is the significance…
A: Single-cell proteins are the proteins that are edible and are derived from single-celled organisms.…
Q: Acyclovir can be used to treated virus-infected cells. Explain how?
A: Acyclovir is an antiviral medication which is primarily used for the treatment of viral disesases…
Q: AZT (zidovudine) inhibits the synthesis of the HIV virus RNA because AZT resembles substrate…
A: AZT is a antiretroviral medication used to prevent and threat HIV/AIDS. It is generally recommended…
Q: If you Infect the Jurkat T lymphocyte cell line with HIV-1 strain IIIB. Lyse the infected cells at…
A: A virus is a microscopic infectious agent that could infect and live only within the living…
Q: what Mutations that cause penicillin resistance
A: Mutation is a sudden change in the structure of gene which results into a variant form that can be…
Q: Describe the mechanism through which oseltamivir (Tamiflu) inhibits influenza virus reproduction.
A: Oseltamivir (also known as TamifluR) is an antiviral neuraminidase inhibitor used to treat and…
Q: Why can protease inhibitors and nucleoside analogs be used in minimizing the replication of the HIV…
A: Protease is an enzyme in the body that's important for HIV replication
Q: Explain the role of RNase H (a component of reverse transcriptase)during the synthesis of HIV DNA.
A:
Q: Explain how oseltamivir (Tamiflu) interferes with influenza virus replication.
A: The influenza virus is commonly known as the flu virus. An individual suffering from flu may…
Q: Many patients become resistant to HIV protease inhibitors with the passage of time, owing to…
A: HIV is the human immunodeficiency virus that causes immune deficiency syndrome in humans. They are…
Q: What is the advantage of using genetic engineering to makeinsulin?
A: In the plasmid, the gene for human insulin is first inserted into the gap. Then this plasmid is…
Q: A conjugate was incubated with a mixture of lysosomal enzymes and no drug release was observed in…
A: Lysosomes contain a wide variety of hydrolytic enzymes including proteases, nucleases, glycosidases,…
Q: What is antiterminator hairpin ?
A: It is a secondary structure of RNA. It determines interaction in ribozyme and can help in RNA…
Q: What is the mechanism that makes Bacteria resistant to Beta-lactams
A: The majority of bacteria are composed structurally of a cell membrane that is encased in a cell…
Q: Which bacteria produce β-lactamase enzyme which is resistant to penicillin and why?
A: Prokaryotes are the primitive organisms that were the first to develop and harness life on Earth.…
Q: During HAART therapy for Human Immunodeficiency Virus (HIV), what are the rationale and mechanisms…
A: HAART: Multiple antiretroviral medications are typically used in the treatment of HIV/AIDS in order…
Q: Please help explain this LAPTM5 Transport HIV-1 Env to the lysosome for degradation
A: Answer
Q: Nucleoside and nucleotide analogs are two closely related classes of anti-viral drugs that inhibit…
A: Nucleoside and nucleotide analogs are two classes of antiviral drugs. The difference between the two…
Q: Explain what is the agglutination reaction: WHAT agglutinates with what? Agglutination is the…
A: Agglutination reaction is related with the blood group of humans. Blood type in humans is broadly…
Q: Which of the followings is/are regulated by proteolytic cleavage?
A: Proteolytic cleavage is the process through which proteolytic activation of an enzyme occurs. The…
Q: What does penicillin binding protein do?
A: Penicillins are the secondary metabolites produced by the bacteria which is used as an antibiotic.…
Q: Make a list of five preventive measures you and your family continuously practice to stop the spread…
A: Coronavirus disease (COVID-19): is an infectious disease caused by the SARS-CoV-2 virus. The…
Q: What is the role of the penicillin-binding protein FtsIin cell division?
A: Cell division is the biological process that results in the production of two or more cells from a…
Q: Why is HIV protease a good target for anti-HIV therapy and drug discovery?
A: HIV protease is a retroviral aspartyl protease which is an enzyme that is involved with peptide bond…
Q: What role does the Env trimer play in HIV infection?
A: The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the…
Q: Discuss RNA-Seq and its application in the study ofbacterial responses to heat shock.
A: RNA-seq (RNA-sequencing): This is a technique that can examine the quantity and sequences of RNA in…
Q: Which of the following drugs inhibits protein synthesis through binding to ribosomal 30S subunit: a.…
A: Aminoglycide class of drugs works by irreversibly binding to the site on the bacterial 30S ribosome,…
Q: Briefly describe how bacteriorhododpsin works?
A: Bacteriorhodopsin is a membrane protein found inside the cell membrane, generally on the crystalline…
Ritonavir inhibits the action of HIV protease. What kind of inhibition is imposed on HIV protease by ritonavir?
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- present the chemical mechanism of the HIV protease. Discuss the mode of action of some inhibitors of this enzyme.Draw the mechanism of action of an HIV protease. Label the substrate, the intermediates, and the products. Indicate each type of catalysis that occurs throughout the mechanism..Explain what is TFIID ?
- What is application of D_serine?Part A What kind of inhibition is imposed on HIV protease by ritonavir? O irreversible inhibition O reversible inhibition O uncompetitive inhibition. Submit Request AnswerDuring HAART therapy for Human Immunodeficiency Virus (HIV), what are the rationale and mechanisms of action for NRTIs, NNRTIs, and protease inhibitors?
- Under cellular conditions, dATP can be oxidized to its 2-hydroxy form, which is a substrate for an enzyme that converts 2-OH-dATP to 2-OH-dAMP + PPi. Explain why compounds that inhibit the activity of this enzyme would be eff ective anticancer agents.Why are protease inhibitors an effective treatment forhuman AIDS?Which letter represents the target site of furosemide (Lasix)? E- -B