Syt1 point mutation is a point mutation in synaptotagmin-1. A. How did the experiment shown in the figure below show that synaptotagmin was probably the Ca²+ sensor? of synaptic response 1.5 1.0 50.5 Syt1 point mutation wild type (MM) 10

Syt1 point mutation is a point mutation in synaptotagmin-1. A. How did the experiment shown in the figure below show that synaptotagmin was probably the Ca²+ sensor? of synaptic response 1.5 1.0 50.5 Syt1 point mutation wild type (MM) 10

Biomedical Instrumentation Systems

1st Edition

ISBN:9781133478294

Author:Chatterjee

Publisher:Chatterjee

Chapter17: Instrumentation In Intensive Care Units

Section: Chapter Questions

Problem 6P

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Concept explainers

Immunology

Immunology is the division of science involved with the immune reactions occurring in living organisms. The organisms are accustomed to evolving internal defense mechanisms to evade the invasion of microbial pathogens. Diverse cells are connected with stimulating the immune responses, which produce inhospitable conditions to the microbes prompting their lysis and thus inhibits the multiplication of the pathogens. The immune system can distinguish the pathogens through the aid of cellular intercommunication and launch responses to destroy them.

Question

100%

Syt1 point mutation is a point mutation in synaptotagmin-1.
A. How did the experiment shown in the figure below show that synaptotagmin was
probably
the Ca²+ sensor?
normalized amplitude
of synaptic response
1.5
1.0
0.5
-Syt1 point mutation
- wild type
Ca²+ (mm)
10

Expert Solution

Step 1

Synaptotagmin-1, a protein that detects calcium ions at synapses, collaborates with the SNARE complex, a collection of proteins, to aid in the fusion of vesicles with cell membranes. Three distinct structures of synaptotagmin-1 coupled to the SNARE complex have been described in earlier research. Which of these binding states, though, truly causes the release of neurotransmitters was unclear.

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