The distance between the porphyrin plane and proximal histidine is longer in T-state than that in R-state, why? Explain with a neat illustration.
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A: The oxidation of D-aldopentose to an optically active aldaric acid is given below.
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A: The reason is give below:
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A: Solution -
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A: stereogenic centers are optically active centers.
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Q: Explain why cyanogen bromide does not cleave on the C-side of cysteine
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A: The stereogenic center of clopidogrel and 10-camphor sulfonic acid structure is given in picture 1.
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- Isoleucine and threonine are the only two amino acids with two chirality centers. Assign R or S configuration to the methyl-bearing carbon atom of isoleucine.3a. 3b. 3c 3d. 3e. CO₂ clavulanic acid CH₂-OH H Answer the following questions about clavulanic acid. Does clavulanic acid inhibit D-alanyl-D-alanine transpeptidase? Does clavulanic acid contain a ß-lactam? Does clavulanic acid contain a thiazolium ring? What is the result of the treatment of penicillinase with clavulanic acid? Does clavulanic acid form a covalent acyl-enzyme intermediate with penicillinase?Write out a scheme for the resolution of the two enantiomers of theantiplatelet drug clopidogrel with 10-camphorsulfonic acid.
- An enzymatic assay was performed using the enzyme phophofructokinase-1, which catalyses the committed step of the glycolysis pathway. What is the final concentration of the fructose 6-phosphate substrate in a test tube containing the following: 250 µL of 150pM fructose 6-phophate, 100 µL 20 mg.ml-1 phosphofructoskinase-1 and 150 µL 100mM buffer pH 7.55- which of the following structures represent meso compounds? (a) (b) H. OH H. H.Trypsin is a serine protease that has a KM of 15 mM. At an initial substrate concentration of 250 µM insulin, trypsin is found to degrade insulin at a rate of 0.6 µM/min. If the concentration of trypsin in solution was 4.326 µM, what is the kcat of trypsin in s-1?
- (а) DCC/HОBT Show a detailed mechanism for the coupling of N-acetyl-L-proline to L-ValOBn using (b) diastereomer. However, when coupling N-acetyl-L-alanine to L-ValOBn using DCC, the resulting dipeptide is a mixture of two diastereomers. Why is this? Your answer should include a detailed mechanism. When N-acetyl-L-proline is coupled to L-ValOBn using DCC the resulting dipeptide is a single9. Phosphotyrosine (shown below) has four ionizable functional groups (pK1 = 2.5, pKR1 = 2.1, pKr2 = 7.2, pK2 = 9.5). (a) Write the equilibrium equation for its four ionization forms and assign the proper pka for each ionization. DRAW the structure of phosphotyrosine in each ionization state. What is the net charge on the phosphotyrosine molecule in each ionization state? *H3N. pk2 - 9.5 .COOH pK, - 2.5 O=P-OH pKRI - 2.1 ÖH pKRI - 7.2 (b) Draw the titration curve of phosphorotyrosine and indicate each pKa and the isoelectric point (pl), indicate the molar equivalents of OH on the x-axis.What is the ratio of CATION to ANION in Drug X? [blank1] H₂C -H Fogy CH3 SO42 'N CH3 Drug X CH3NH Describe the possible interactions between the SIDE CHAINS of amino acids: I. and II.... II. and III... I. and III... 1. COO NH3* 2 HO II. COO HO NH3* COO NH3* III.
- 1a) Biotin has a single ionizable group with a pKa of 4.5. If you dissolved biotin in an aqueous solution at pH 7.0, would this ionizable group be protonated or deprotonated? Briefly explain why the molecule would be in that form at pH 7.0.When are the α and β forms not interconvertible?What are the R/S configurations of the sterogenic centers in this molecule?