The sigmoidal, cooperative binding curve commonly observed for hemoglobin is a result of: a) competition between CO2 and O2 for heme binding. B) competition between heme and distal His for O2 binding c) competition between BPG and CO2 for binding at the central cavity site d) T to R transitionHemoglobin has a tendency to release its oxygen to the tissues because: a) in this region pH is high and O2 concentrations are low b) in this region both pH and O2 concentrations are low c) in this region both pH and O2 concentrations are high d) there is much BPG in this regionWhich statement about fetal hemoglobin is not true? A) fetal hemoglobin has gamma chains instead of beta chains b) fetal hemoglobin binds BPG less strongly than maternal hemoglobin c) fetal hemoglobin binds oxygen less strongly than maternal hemoglobin d) fetal hemoglobin binds oxygen more strongly than maternal hemoglobin Which process is most responsible for the sickling of cells seen in sickle cell disease? A) aggregation of the oxygenated R form of hemoglobin-S to form insoluble fibers b) aggregation of the deoxygenated T form of hemoglobin-S to form insoluble fibers c) Hemoglobin-S does not contain heme d) Hemoglobin-S contains a mutant form of heme which will not bind oxygenA person with sickle-cell trait is very unlikely to catch which disease? A) malaria b) colon cancer c) avian flu d) whooping cough

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Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter10: The Respiratory System

Section: Chapter Questions

Problem 4RQ: What is oxyhemoglobin? Where does it form?

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The sigmoidal, cooperative binding curve commonly observed for hemoglobin is a result of: a) competition between CO₂ and O₂ for heme binding. B) competition between heme and distal His for O₂ binding c) competition between BPG and CO₂ for binding at the central cavity site d) T to R transition
Hemoglobin has a tendency to release its oxygen to the tissues because: a) in this region pH is high and O₂ concentrations are low b) in this region both pH and O₂ concentrations are low c) in this region both pH and O₂ concentrations are high d) there is much BPG in this region
Which statement about fetal hemoglobin is not true? A) fetal hemoglobin has gamma chains instead of beta chains b) fetal hemoglobin binds BPG less strongly than maternal hemoglobin c) fetal hemoglobin binds oxygen less strongly than maternal hemoglobin d) fetal hemoglobin binds oxygen more strongly than maternal hemoglobin
Which process is most responsible for the sickling of cells seen in sickle cell disease? A) aggregation of the oxygenated R form of hemoglobin-S to form insoluble fibers b) aggregation of the deoxygenated T form of hemoglobin-S to form insoluble fibers c) Hemoglobin-S does not contain heme d) Hemoglobin-S contains a mutant form of heme which will not bind oxygen
A person with sickle-cell trait is very unlikely to catch which disease? A) malaria b) colon cancer c) avian flu d) whooping cough

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