What would you expect if a patient carries a mutation in Hexokinase IV (HKIV) that lowers the Km from 10mM to 4mM? O HKIV is still regulated by its product G6P so nothing will change O This change is irrelevant since HKIV is only expressed in muscle cells O mutant HKIV will have a greater change in reaction velocity in response to change in Glucose levels O mutant HKIV will have a reduced change in reaction velocity in response to change in Glucose levels O Mutant HKIV will always be less saturated by glucose compared to WT HKIV

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter27: Metabolic Integration And Organ Specialization
Section: Chapter Questions
Problem 18P
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What would you expect if a patient carries a mutation in Hexokinase IV (HKIV) that lowers the Km from 10mM to 4mM?
O HKIV is still regulated by its product G6P so nothing will change
This change is irrelevant since HKIV is only expressed in muscle cells
mutant HKIV will have a greater change in reaction velocity in response to change in Glucose levels
O mutant HKIV will have a reduced change in reaction velocity in response to change in Glucose levels
O Mutant HKIV will always be less saturated by glucose compared to WT HKIV
Transcribed Image Text:What would you expect if a patient carries a mutation in Hexokinase IV (HKIV) that lowers the Km from 10mM to 4mM? O HKIV is still regulated by its product G6P so nothing will change This change is irrelevant since HKIV is only expressed in muscle cells mutant HKIV will have a greater change in reaction velocity in response to change in Glucose levels O mutant HKIV will have a reduced change in reaction velocity in response to change in Glucose levels O Mutant HKIV will always be less saturated by glucose compared to WT HKIV
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