Which of the following is FALSE about Insulin?O Zinc plays a role in the synthesis, storage, and secretion of insulin and binds insulin in the hexameric form.O Type 2 diabetes patients are resistant to the effects of Insulin.O Animal-sourced insulin (taken from the pancreases of pigs) is currently the largest and safest source of insulinproduction.O Lispro insulin is fast acting because it is mutated to prevent dimerization.

Insulin is a hormone that regulates the sugar levels in the blood. High blood sugar is very harmful…

Answered: Which of the following is FALSE about…

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter23: Endocrine System Drugs

Section: Chapter Questions

Problem 15CRQ

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Cells of an overactive thyroid can be killed by radioactive iodine. Explain why the thyroids hormone-producing cells take up more radioactive iodine than other cells of the body.
Figure 37.11 Pancreatic tumors may cause excess secretion of glucagon. Type I diabetes results from the failure of the pancreas to produce insulin. Which of the following statement about these two conditions is true? A pancreatic tumor and type I diabetes will have the opposite effects on blood sugar levels. A pancreatic tumor and type I diabetes will both cause hyperglycemia. A pancreatic tumor and type I diabetes will both cause hypoglycemia. Both pancreatic tumors and type I diabetes result in the inability of cells to take up glucose.
Which of the following statements is true for the shown reactions? Deficiency of oxaloacetate stimulates the formation of X and y Insulin signaling stimulates the formation of X and Y Both A and B Neither A nor B
Lantus differs from "normal" insulin in that: Select one: Oa. The usual insulin molecule has been combined with zinc isophane Ob. A glycine has been substituted in at A21, and two new arginines have been added as B31 and B32 *. An aspartic acid has been substituted for proline at B28 Od. A "C-peptide" chain has been added Oe The proline at B28 and the lysine at B29 have been reversed
Which of the following are true about how pancreatic β cells sense blood glucose levels and release insulin? (select all that apply) Group of answer choices The first step of glycolysis (producing glucose 6-phosphate) is more efficient in pancreatic β cells than in muscle glucose transporters in pancreatic β cells have a higher affinity for glucose than the transporters in other tissues Increased production of ATP is used as a signal that blood glucose is high Insulin is released when blood glucose levels are high Increases in ATP open a K+ channel Influx of Ca2+ stimulates insulin release
People with non-insulin-dependent diabetes mellitus are generally not ketosis prone. This is thought to be a result of: the lack of increase in glucagons in the se individuals the presence of insulin in the individuals their obesity the fact that, their blood glucose levels do not tend to rise significantly Metabolic actions of insulin include all of the following except: increased glycogenesis decreased gluconeogenesis increased basal metabolic rate increased skeletal muscle amino acid up-take all of the above are metabolic actions of insulin
Why is it physiologically advantageous for the pancreas to use GLUT2, with a high Ky glucose entry into ß cells? M, as the transporter that allows GLUT2 is a low-affinity glucose transporter; therefore, insulin is only released in response to elevated circulating glucose levels. GLUT2 is a low-affinity glucose transporter; therefore, glucagon is only released in response to elevated circulating glucose levels. GLUT2 is a high-affinity glucose transporter; therefore, glucagon is released continuously in response to the constant rate of glucose uptake. GLUT2 is a high-affinity glucose transporter; therefore, insulin is released continuously in response to the constant rate of glucose uptake.
Compare and contrast the formulations insulin lispro, insulin aspart and protamine zinc insulin. Describe how the structure and properties of the formulation help control the rate and which insulin enters bloodstream.
Which of the following is a consequence of insulin signaling? (select all that apply) Cell growth/division genes upregulated Increased cellular glucose uptake through GLUT4 transporter glycogen degradation Glucose synthesis
All of the following increase insulin secretion/production EXCEPT: Select one or more: a. Increased intracellular Ca²+ levels O b. Acetylcholine O C. Ghrelin O d. High carbohydrate meal e. Incretins O f. Sometostatin
Which of the following enzymes are activated after insulin binds to its receptor? (select all that apply) Protein Phosphatase-1 Glycogen Synthase Lipase Acetyl CoA Carboxylase Glycogen phosphorylase Glycogen phosphorylase kinase
Which of the following statements is true regarding the blood glucose level of non-insulin-dependent diabetics compared with that of normal individuals? O Blood glucose levels of diabetics tend to be very stable, but at a higher level. O Blood glucose levels of diabetics tend to be variable and higher. O Blood glucose levels decrease more rapidly following a meal, often dropping lower than is toleráble. O Blood glucose levels average the same level in diabetics but reach higher peaks for short periods. O None of the above is true.

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