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- What is the rate limiting step in catecholamines synthesis ?How many high-phosphoryltransferpotential molecules are required to synthesize phosphatidylethanolamine from ethanolamine and diacylglycerol? Assume that the ethanolamine is the activated component.Psilocybin is rapidly de-phosphorylated in the body into psilocin, which is anagonist For the 5-HT 2A Serotonin receptor, which binds the neurotransmitter serotonin as its natural ligand, and acts as a ligand-gated ion channel in the central nervous system. HO. Serotonin (a) Part of the sequence of the 5-HT 24 Receptor is NH₂ ...RQKACKVIGIVFFLFVVMWLAFFITNICDES... Identify the trans-membrane region within this sequence. Do you predict this sequence will Be transmembrane a-Helix or ß sheet? Why? (b) What is the distance spanned by this transmembrane region?
- Under what conditions might receptor up-regulation occur? receptor down-regulation?name and describe the isoforms of the leptin receptor.What functional group interactions between the cate- cholamines and adrenoceptors are most likely? Which functional groups are considered pharmacophores of catecholamines?
- What would be the most direct result if NAG (N-acetylglucosamine acid) could not be synthesized?The NMDA receptor I/V curve is nonlinear, why? What about the GluA2-containing AMPA receptor I/V curve? Draw both under normal physiological conditions. In addition, explain what happens for the NMDA receptor I/V curve when you lower the magnesium concentration.Write schematically the synthesis of phosphatidylcholine from phosphatidylethanolamine. What compounds are necessary for this biochemical process? Biological significance of phospholipids.