You are designing a study comparing Treatments A and B. You expect an enrollment rate of 150 subjects per year. From previous data, you expect exponential distributions for the survival times of each treatment, and that treatment B's mean survival time is 3 years. You want to detect that Treatment A will have a 4 year mean survival time, using a two-sided log-rank test with 90% power and an alpha of 0.05. Assuming an enrollment stage of 5 years, how long should the study be? If you use a statistical program to solve this, please include the code.
You are designing a study comparing Treatments A and B. You expect an enrollment rate of 150 subjects per year. From previous data, you expect exponential distributions for the survival times of each treatment, and that treatment B's mean survival time is 3 years. You want to detect that Treatment A will have a 4 year mean survival time, using a two-sided log-rank test with 90% power and an alpha of 0.05. Assuming an enrollment stage of 5 years, how long should the study be? If you use a statistical program to solve this, please include the code.
Calculus For The Life Sciences
2nd Edition
ISBN:9780321964038
Author:GREENWELL, Raymond N., RITCHEY, Nathan P., Lial, Margaret L.
Publisher:GREENWELL, Raymond N., RITCHEY, Nathan P., Lial, Margaret L.
Chapter1: Functions
Section1.EA: Extended Application Using Extrapolation To Predict Life Expectancy
Problem 5EA
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You are designing a study comparing Treatments A and B. You expect an enrollment rate of 150 subjects per year. From previous data, you expect exponential distributions for the survival times of each treatment, and that treatment B's
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