You have a patient slated to undergo somatic cell gene therapy to alleviate a cystic fibrosis disease state. Cystic fibrosis is the result of homozygous recessive mutations in the CFTR gene. The patient is very concerned about the potential side effects of new DNA insertions causing cancer. Which treatment(s) would you recommend that would avoid this issue?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter15: Genomes And Genomics
Section: Chapter Questions
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Answer question 28

You have a patient slated to undergo somatic cell gene therapy to alleviate a
cystic fibrosis disease state. Cystic fibrosis is the result of homozygous
recessive mutations in the CFTR gene. The patient is very concerned about
the potential side effects of new DNA insertions causing cancer. Which
treatment(s) would you recommend that would avoid this issue?
AAV and RTV
CRISPR and RTV
AAV, RTV and CRISPR
RTV only
AAV only
Transcribed Image Text:You have a patient slated to undergo somatic cell gene therapy to alleviate a cystic fibrosis disease state. Cystic fibrosis is the result of homozygous recessive mutations in the CFTR gene. The patient is very concerned about the potential side effects of new DNA insertions causing cancer. Which treatment(s) would you recommend that would avoid this issue? AAV and RTV CRISPR and RTV AAV, RTV and CRISPR RTV only AAV only
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