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You have mutated Trypsin by replacing Asp 189 in the specificity pocket with Arginine. Which substrates (from the list below) your mutant protease would cleave? Assume that you are cleaving the bond shown in red. RN and Rc-denote the N and the C termini of your protein on either side of the bond. Select ALL that applies: Arg 189. Arg Trypsin D189R mutant RN-Asp---Glu-Rc RN-Glu---Met-Rc RN-Phe---Val-Rc RN-Met-Lys-Rc RN-Val---Asp-Rc RN-Val---Met-Rc RN-Lys-Met-Rc

You have mutated Trypsin by replacing Asp 189 in the specificity pocket with Arginine. Which substrates (from the list below) your mutant protease would cleave? Assume that you are cleaving the bond shown in red. RN and Rc-denote the N and the C termini of your protein on either side of the bond. Select ALL that applies: Arg 189. Arg Trypsin D189R mutant RN-Asp---Glu-Rc RN-Glu---Met-Rc RN-Phe---Val-Rc RN-Met-Lys-Rc RN-Val---Asp-Rc RN-Val---Met-Rc RN-Lys-Met-Rc

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question 18 (- You have mutated Trypsin by replacing Asp 189 in the specificity pocket with Arginine. Which substrates (from the list below) your mutant protease would cleave? Assume that you are cleaving the bond shown in red. RN and Rc-denote the N and the C termini of your protein on either side of the bond. Select ALL that applies: Arg 189. Arg Trypsin D189R mutant RN-Asp---Glu-Rc RN-Glu---Met-Rc RN-Phe---Val-Rc RN-Met---Lys-Rc RN-Val---Asp-Rc RN-Val---Met-Rc RN-Lys-Met-Rc
Transcribed Image Text:Question 18 (- You have mutated Trypsin by replacing Asp 189 in the specificity pocket with Arginine. Which substrates (from the list below) your mutant protease would cleave? Assume that you are cleaving the bond shown in red. RN and Rc-denote the N and the C termini of your protein on either side of the bond. Select ALL that applies: Arg 189. Arg Trypsin D189R mutant RN-Asp---Glu-Rc RN-Glu---Met-Rc RN-Phe---Val-Rc RN-Met---Lys-Rc RN-Val---Asp-Rc RN-Val---Met-Rc RN-Lys-Met-Rc
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