Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Textbook Question
Chapter 20.2, Problem 1CC
Does the apical membrane of a collecting duct cell have more water pores when vasopressin is present or when it is absent?
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Certain diseases, kidney trauma, heavy metals, and some bacterial toxins can damage the filtration membrane. What effect would this have on relative permeability of the membrane and the substances that are filtered?
One model of the glomerular membrane is a microporous membrane in which right cylindrical pores penetrate all the way through the membrane. Assume that the pores have a length of 50 nm and a radius of 3.5 nm. The viscosity of plasma is 0.002 Pa s. The average hydrostatic pressure in the glomerulus is 60 mm Hg, hydrostatic pressure in Bowman's space is 20 mm Hg and the average oncotic pressure of glomerular capillary blood is 28 mm Hg. A. Calculate the flow through a single pore assuming laminar flow (use the Poiseuille flow equation) B. How many pores would there have to be to produce a normal GFR? C. If the total aggregate area of the kidneys for filtration is 1.5 m2, what is the density of the pores (number of pores per unit area)? D. What fraction of the area is present as pores?
Blood in renal efferent arterioles is
compared to systemic arterial blood.
hypertonic
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isotonic
Chapter 20 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 20.2 - Does the apical membrane of a collecting duct cell...Ch. 20.2 - Prob. 2CCCh. 20.2 - A scientist monitoring the activity of...Ch. 20.2 - If vasopressin increases water reabsorption by the...Ch. 20.2 - Experiments suggest that there are peripheral...Ch. 20.2 - Prob. 6CCCh. 20.2 - Prob. 7CCCh. 20.3 - In Figure 20.9b, what forces cause Na+ and K+ to...Ch. 20.3 - Prob. 9CCCh. 20.3 - Laboratory values for ions may be reported as...
Ch. 20.3 - A man comes to the doctor with high blood...Ch. 20.3 - Map the pathways through which elevated renin...Ch. 20.3 - Why is it more efficient to put ACE in the...Ch. 20.5 - Incorporate the thirst reflex into Figure 20.8.Ch. 20.6 - Map the pathway that begins with renal artery...Ch. 20.7 - CO2+H2OH++HCO3(6) In equation 6, the amount of...Ch. 20.7 - Why is ATP required for H+ secretion by the H+-K+...Ch. 20.7 - In hypokalemia, the intercalated cells of the...Ch. 20 - What is an electrolyte? Name five electrolytes...Ch. 20 - Prob. 2RQCh. 20 - Prob. 3RQCh. 20 - List the receptors that regulate osmolarity, blood...Ch. 20 - How do the two limbs of the loop of Henle differ...Ch. 20 - Prob. 6RQCh. 20 - Prob. 7RQCh. 20 - Prob. 8RQCh. 20 - Write out the words for the following...Ch. 20 - Prob. 10RQCh. 20 - Prob. 11RQCh. 20 - Prob. 12RQCh. 20 - Prob. 13RQCh. 20 - Prob. 14RQCh. 20 - Prob. 15RQCh. 20 - When ventilation increases, what happens to...Ch. 20 - Prob. 17RQCh. 20 - Figures 20.15 and 20.18a show the respiratory and...Ch. 20 - Explain how the loop of Henle and vasa recta work...Ch. 20 - Prob. 20RQCh. 20 - Prob. 21RQCh. 20 - Name the four main compensatory mechanisms for...Ch. 20 - Prob. 23RQCh. 20 - Compare and contrast the terms in each set: a....Ch. 20 - Prob. 25RQCh. 20 - Prob. 26RQCh. 20 - Prob. 27RQCh. 20 - Hannah, a 31-year-old woman, decided to have...Ch. 20 - Prob. 29RQCh. 20 - Prob. 30RQCh. 20 - The Henderson-Hasselbalch equation is a...Ch. 20 - Hyperglycemia in a diabetic patient leads to...Ch. 20 - Osmotic diuresis refers to the loss of additional...
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- Why does having water and blood flow in opposite directions increase transfer efficiency?arrow_forwardList the two mechanisms by which tubule and collecting duct cells generate new HCO3−.arrow_forwardEpithelial cells that reabsorb solutes are cuboidal, but epithelial cells involved in filtration are thin, squamous cells. The cuboidal cells contain more cytoplasm and organelles, especially mitochondria and rough endoplasmic reticulum (RER), than the squamous cells. Why do the cuboidal cells of the kidney tubules need more mitochondria and RER?arrow_forward
- Name the gland whose secretion is vasopressin.arrow_forwardWhy is this process considered secondary active transport? Does water reabsorption accompany ion reabsorption in this region of the nephron?arrow_forwardFor part A, explain why the solution inside the dialysis tubing turned blue, but the solution in the surrounding beaker did not.arrow_forward
- What three stimuli control vasopressin secretion? What is the most potent stimulus for vasopressin release?arrow_forwardWhat is the role of the disulfide bond in oxytocin and vasopressin?arrow_forwardIn the presence of anti-diuretic hormone (ADH), which of the following does NOT occur? OAquaporins will be present ONLY in the apical membrane of the collecting duct ADH will bind to an ADH receptor, which is a metabotropic receptor O Adenylate cyclase will be activated, producing CAMP OWater flows down its concentration gradient, from high to low solute concentrations OAll of the above would occurarrow_forward
- The mammalian kidney contains an immense network of nephrons that functions to conserve water by producing urine that is hyperosmotic compared to other body fluids. Explain how the transport epithelia of the nephron and collecting duct are able to use transport mechanisms to process the filtrate as it moves through the vessels and produce a hyperosmotic filtrate.arrow_forwardBlood volume must be restored in a person who has lost large amounts of blood due to serious injury. This is often accomplished by infusing isotonic NaCl solution into the blood. Why is this more effective than infusing an isoosmotic solution of a penetrating solute, such as urea?arrow_forwardDescribe the countercurrent exchange system that maintains the concentration gradient.arrow_forward
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