Homework Help is Here – Start Your Trial Now!
Science
Chemistry
9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...

9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...

Introduction to General, Organic and Biochemistry
Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter21: Lipids
Section: Chapter Questions
Problem 21.18P
See similar textbooks
icon
Related questions
Question
Past paper question
9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...
Transcribed Image Text:9. Answer ALL parts of this question. (a) Acetylcholine (ACh) is a neurotransmitter that is found in the central and-peripheral nervous systems. Its receptors are grouped into two main types which are named after the natural products that show receptor selectivity. (b) + N Mе3 Acetylcholine (i) Name the two receptor types. (2 marks) (ii) Acetylcholine is easily made in the laboratory; however, it is a poor drug candidate, briefly explain why that is the case. (3 marks) (iii) Considering the natural products, referred to in (a)(i), are selective for a given type of ACh receptor, why are they not used as drugs? (3 marks) The four drug candidates shown in Figure Q9(b) are potential cholinergic agonists. However, only one is active and is also the most stable with respect to hydrolysis. Select the structure that you think is a cholinergic agonist and explain your choice by comparing its structural features with ACh and the other candidates. Me Me. NH Me NH N Me3 H₂N ཚིག་ Me N Et3 II Me N EtMe2 Me N EtMe2 H₂N III IV Figure Q9(b) 4 (8 marks) Question 9 continued on page 5...
Expert Solution
steps

Step by step

Solved in 2 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Introduction to General, Organic and Biochemistry
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning
SEE MORE TEXTBOOKS