ATROVENT Nasal Spray contains 0.03% w/v of ipratropium bromide in a 30-mL metered dose container. If the container is calibrated to deliver 345 sprays, calculate (a) the volume of each spray, in microliters, and (b) the number of milligrams of ipratropium bromide in each spray.
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ATROVENT Nasal Spray contains 0.03% w/v of ipratropium bromide in a 30-mL
metered dose container. If the container is calibrated to deliver 345 sprays,
calculate (a) the volume of each spray, in microliters, and (b) the number of
milligrams of ipratropium bromide in each spray.
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- ASSAY Calibration solutions Calibration solutions of naproxen in the range 5 – 25 μg/mL were prepared. Sample preparation 20 tablets weighing 12.3819 g were crushed to a fine powder. A portion of the powder (145.4 mg) was shaken with approximately 150 mL of acetic acid (0.05 M) for 5 min and then made up to volume in a 250 mL volumetric flask (stock solution). Approximately 50 mL of the stock solution was filtered and a 25 mL aliquot was diluted to 100 mL in a volumetric flask. 10 mL of the resulting solution was further diluted to 100 mL with acetic acid (0.05 M). Analysis The standards and sample solutions were analyzed by HPLC under the following conditions: Column: octadecylsilyl (ODS), 4.6 mmx150 mm, mobile phase: acetonitrile : 0.05 M acetic acid (85:15), flow rate: 1 ml/min, UV detection at 243 nm. Results: A calibration curve of concentration versus peak area was constructed for the standard solutions and gave the straight-line equation: y = 3555.6x + 85, r = 0.9999 The area…Two aqueous hydrogen bromide solutions containing 1.00 wt% HBr (SG=1.0041) and 60.0 wt% HBr (SG=1.6731) are mixed to form a 3.54 M HBr solution (SG=1.1935). What feed rate of the 60.0 wt% HBr solution would be required to produce 1350 kg/hr of product?Chemical Reactions: Molecular Equation: HCl(aq) + NaOH(aq) NaCl(aq) + H₂O( Net lonic Equation: H(aq) + OH(a (aq) Trial 1 Details Molarity of HCI Standard Solution Volume (mL) HCI Standard Solution No. of mmoles |HC| = No. of mmoles H+ No. of mmoles OH reacted with HCI No. of mmoles NaOH reacted with HCI Final Reading (mL) NaOH Buret Initial Reading (mL) NaOH Buret 25.00 22.17 0.05 → H₂O() Trial 2 0.1024 25.00 22.15 0.05